Role of metabolic syndrome components in human immunodeficiency virus-associated stroke.
Role of metabolic syndrome components in human immunodeficiency virus-associated stroke.
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DOI：
10.1080/13550280902962443
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发表时间：
2009-05
影响因子：
3.2
通讯作者：
HIV Neurobehavioral Research Center (HNRC) Group
中科院分区：
文献类型：
--
作者：
Ances BM;Bhatt A;Vaida F;Rosario D;Alexander T;Marquie-Beck J;Ellis RJ;Letendre S;Grant I;McCutchan JA;HIV Neurobehavioral Research Center (HNRC) Group
代谢综合征（MetS）是一组风险因素，包括平均动脉压（MAP）升高、致动脉粥样硬化性血脂异常（甘油三酯[TRG]升高）、腹部肥胖（体重指数[BMI]增加）、葡萄糖耐受不良（葡萄糖[GLU]升高）和血栓前/炎症状态（尿酸[UA]升高），这些风险因素与脑血管疾病风险增加相关。我们研究了MetS成分与人类免疫缺陷病毒（HIV）相关的隐源性卒中之间是否存在相关性，这些卒中不是由HIV并发症、心内膜炎或兴奋剂滥用引起的。我们进行了一项回顾性病例对照研究。从2346名HIV感染者（HIV+）中确定了11例隐源性卒中。每个病例的年龄、性别和中风诊断日期与5名无中风的HIV阳性对照相匹配。非参数分层Wilcoxon秩和检验和随后的混合效应logistic回归确定了每个MetS组分对HIV相关隐源性卒中的影响。尽管HIV+隐源性卒中患者的MetS各组分均高于HIV+对照组，但仅MAP（比值比[OR] = 5.70，95%置信区间[CI] = 1.15-28.3）和UA（OR = 1.88，95% CI = 1.06-3.32）存在统计学差异。与HIV+对照组（6/55 = 11%）相比，HIV相关隐源性卒中病例符合MetS标准的百分比显著更高（4/11 = 36%）。这项观察性研究表明MetS组分在HIV+隐源性卒中病例中可能发挥作用。虽然代谢综合征被定义为一系列疾病，但高血压和高尿酸血症可能参与卒中的发病机制。因此，降低HIV+患者的MetS组分水平可以保护他们免受随后的中风。
Metabolic syndrome (MetS) is a cluster of risk factors, including elevated mean arterial pressure (MAP), atherogenic dyslipidemia (elevated triglycerides [TRG]), abdominal obesity (increased body mass index [BMI]), glucose intolerance (elevated glucose [GLU]), and prothrombotic/inflammatory state (increases in uric acid [UA]), that are associated with increased risk of cerebrovascular disease. We studied if an association existed between MetS components and human immunodeficiency virus (HIV)-associated cryptogenic strokes—those not caused by HIV complications, endocarditis, or stimulant abuse. We performed a retrospective case-control study. Eleven cryptogenic strokes were identified from 2346 HIV-infected (HIV+) participants. Each case was matched by age, sex, and date of stroke diagnosis to five HIV+ controls without stroke. Nonparametric stratified Wilcoxon ranked sum tests with subsequent mixed effect logistic regression determined the influence of each MetS component on HIV-associated cryptogenic stroke. Although each MetS component appeared higher for HIV+ cases with cryptogenic strokes than HIV+ controls, only MAP (odds ratio [OR] = 5.70, 95% confidence interval [CI] = 1.15–28.3) and UA (OR = 1.88, 95% CI = 1.06–3.32) were statistically different. A significantly higher percentage of HIV-associated cryptogenic stroke cases met criteria for MetS (4/11 = 36%) compared to HIV+ controls (6/55 = 11%). This observational study suggests a possible role for MetS components in HIV+ cryptogenic stroke cases. Although MetS is defined as a constellation of disorders, elevated hypertension and hyperuricemia may be involved in stroke pathogenesis. Reducing MetS component levels in HIV+ patients could therefore protect them from subsequent stroke.
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影响因子：
1.8
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