Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence.
Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence.
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DOI：
10.1038/clpt.2008.202
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发表时间：
2008-12
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
众所周知，药物代谢酶 (DME) 的活性在整个身体和性成熟过程中都会发生变化，其中在婴儿期和青春期期间变化最大。目前尚不清楚负责 DME 发育调节的机制。然而，青春期/青春期的激素变化为理解生长和成熟过程中 DME 活性的生化调节提供了理论框架。关于生长激素和性激素潜在影响的重要信息也可以从评估由于生理、病理和/或药理学激素波动而发生的 DME 活性变化的研究中推断出来。总的来说，目前的数据支持这样的假设：青春期 DME 活性的异构体特异性改变是通过性激素和/或生长激素介导的。确定导致 DME 活性发育变化的潜在生化改变的特征将需要额外的研究，其中评估青春期发育过程中 DME 和重要激素轴之间的关系。
Activities of drug metabolizing enzymes (DME) are known to change throughout the course of physical and sexual maturation with the greatest variability noted during infancy and adolescence. The mechanisms responsible for developmental regulation of DME are currently unknown. However, the hormonal changes of puberty/adolescence provide a theoretical framework for understanding biochemical regulation of DME activity during growth and maturation. Important information regarding potential influences of growth and sex hormones can also be extrapolated from studies evaluating changes in activities of DMEs occurring as a consequence of physiologic, pathologic and/or pharmacologic hormonal fluctuations. Collectively, current data support the hypothesis that isoform-specific alterations in DME activity during adolescence are mediated via sex and/or growth hormones. Characterization of the underlying biochemical alterations responsible for developmental changes in DME activity will require additional studies in which relationships between DME and important hormonal axes are evaluated during the course of pubertal development.
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影响因子：
2.5
作者：
CARY, J;HEIN, K;DELL, R
通讯作者：
DELL, R
影响因子：
8
作者：
Euling, Susan Y.;Herman-Giddens, Marcia E.;Swan, Shanna H.
通讯作者：
Swan, Shanna H.
影响因子：
2.5
作者：
BATTINO, D;BOSSI, L;VITALI, A
通讯作者：
VITALI, A
影响因子：
5.8
作者：
KATO, R;CHIESARA, E;FRONTINO, G
通讯作者：
FRONTINO, G
DOI：
10.1016/s0960-0760(98)00145-9
发表时间：
1999-04-01
影响因子：
4.1
作者：
Burger, HG
通讯作者：
Burger, HG