REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease.
REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease.
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DOI：
10.1007/s11910-012-0253-z
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发表时间：
2012-04
影响因子：
5.6
通讯作者：
Boeve, Bradley F.
中科院分区：
文献类型：
--
作者：
McCarter, Stuart J.;St Louis, Erik K.;Boeve, Bradley F.
关键词：
快速眼动（REM）睡眠行为障碍（RBD）是一种以多导睡眠图记录中反复发作的做梦行为和无张力的REM睡眠（RSWA）为特征的异眠症。RSWA的特征在于在多导睡眠图肌电图通道上观察到的增加的阶段性或强直性肌肉活动。RSWA是RBD的一个必要的诊断特征，但也可以在没有临床症状或梦制定的迹象的患者中看到，作为神经正常个体的偶然发现，特别是在接受抗抑郁治疗的患者中。RBD可能是特发性的或有症状的。患有特发性RBD的患者通常随后发展为其他神经系统特征，包括帕金森综合征、直立性低血压、嗅觉丧失或认知障碍。无临床症状的RSWA以及临床上明显的RBD也经常伴随神经退行性疾病的α-突触核蛋白病家族发生，包括特发性帕金森病、路易体痴呆和多系统萎缩。这篇评论文章考虑了RBD的流行病学、RBD和RSWA的临床和多导睡眠图诊断标准、之前报道的RSWA和RBD与神经退行性疾病和其他潜在原因的相关性、大脑结构和网络介导REM睡眠肌肉张力失调的病理生理学，以及有效和安全管理RBD的考虑因素。
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by repeated episodes of dream enactment behavior and REM sleep without atonia (RSWA) during polysomnography recording. RSWA is characterized by increased phasic or tonic muscle activity seen on polysomnographic electromyogram channels. RSWA is a requisite diagnostic feature of RBD, but may also be seen in patients without clinical symptoms or signs of dream enactment as an incidental finding in neurologically normal individuals, especially in patients receiving antidepressant therapy. RBD may be idiopathic or symptomatic. Patients with idiopathic RBD often later develop other neurological features including parkinsonism, orthostatic hypotension, anosmia, or cognitive impairment. RSWA without clinical symptoms as well as clinically overt RBD also often occurs concomitantly with the α-synucleinopathy family of neurodegenerative disorders, which includes idiopathic Parkinson disease, Lewy body dementia, and multiple system atrophy. This review article considers the epidemiology of RBD, clinical and polysomnographic diagnostic standards for both RBD and RSWA, previously reported associations of RSWA and RBD with neurodegenerative disorders and other potential causes, the pathophysiology of which brain structures and networks mediate dysregulation of REM sleep muscle atonia, and considerations for the effective and safe management of RBD.
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影响因子：
4.8
作者：
Boeve, Bradley F.;Molano, Jennifer R.;Ferman, Tanis J.;Smith, Glenn E.;Lin, Siong-Chi;Bieniek, Kevin;Haidar, Wael;Tippmann-Peikert, Maja;Knopman, David S.;Graff-Radford, Neill R.;Lucas, John A.;Petersen, Ronald C.;Silber, Michael H.
通讯作者：
Silber, Michael H.
影响因子：
3.9
作者：
Ferman, Tanis J.;Smith, Glenn E.;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.
影响因子：
5.6
作者：
Dauvilliers, Yves;Rompre, Sylvie;Montplaisir, Jacques
通讯作者：
Montplaisir, Jacques
影响因子：
5.2
作者：
Boeve BF
通讯作者：
Boeve BF
影响因子：
8.6
作者：
Boeve, BF;Silber, MH;Parisi, JE
通讯作者：
Parisi, JE