The BioGRID Interaction Database: 2011 update.
The BioGRID Interaction Database: 2011 update.
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DOI：
10.1093/nar/gkq1116
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Tyers M
中科院分区：
文献类型：
--
作者：
Stark C;Breitkreutz BJ;Chatr-Aryamontri A;Boucher L;Oughtred R;Livstone MS;Nixon J;Van Auken K;Wang X;Shi X;Reguly T;Rust JM;Winter A;Dolinski K;Tyers M
BIOGRID是一个公共数据库，用于存档和传播来自模式生物和人类(http://www.thebiogrid.org).)的遗传和蛋白质相互作用数据BioGRID目前拥有347个 966相互作用(170个 162基因，177个 804蛋白质)，来自高通量数据集和个人重点研究，来自主要文献中超过23个 000出版物。完整的文献涵盖了萌芽酵母(酿酒酵母)、分裂酵母(裂殖酵母)和水芹(拟南芥)，并正在努力扩大对多个后生动物物种的管理。BioGRID包含了48,831种人类蛋白质相互作用，这些相互作用是从10,247种出版物中挑选出来的。目前的管理活动侧重于生物学的特定领域，以使人们能够深入了解与人类健康相关的保守网络和途径。BioGRID 3.0网络界面包含新的搜索和显示功能，可实现跨多种数据类型和来源的快速查询。自动化互动管理系统(IMS)用于对国际网站和项目的管理进行优先排序、协调和跟踪。BioGRID将相互作用数据提供给几个模型生物体数据库、Entrez-gene等资源和其他相互作用元数据库。整个BioGRID 3.0数据收集可以多种文件格式下载，包括PSI MI XML。BioGRID 3.0的源代码是免费提供的，没有任何限制。
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans (http://www.thebiogrid.org). BioGRID currently holds 347 966 interactions (170 162 genetic, 177 804 protein) curated from both high-throughput data sets and individual focused studies, as derived from over 23 000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe) and thale cress (Arabidopsis thaliana), and efforts to expand curation across multiple metazoan species are underway. The BioGRID houses 48 831 human protein interactions that have been curated from 10 247 publications. Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources. An automated Interaction Management System (IMS) is used to prioritize, coordinate and track curation across international sites and projects. BioGRID provides interaction data to several model organism databases, resources such as Entrez-Gene and other interaction meta-databases. The entire BioGRID 3.0 data collection may be downloaded in multiple file formats, including PSI MI XML. Source code for BioGRID 3.0 is freely available without any restrictions.
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