Replication timing maintains the global epigenetic state in human cells.
Replication timing maintains the global epigenetic state in human cells.
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DOI：
10.1126/science.aba5545
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发表时间：
2021-04-23
期刊：
影响因子：
--
通讯作者：
Gilbert DM
中科院分区：
文献类型：
--
作者：
Klein KN;Zhao PA;Lyu X;Sasaki T;Bartlett DA;Singh AM;Tasan I;Zhang M;Watts LP;Hiraga SI;Natsume T;Zhou X;Baslan T;Leung D;Kanemaki MT;Donaldson AD;Zhao H;Dalton S;Corces VG;Gilbert DM
DNA复制的时间顺序（复制时间; RT）与染色质修饰和3D基因组结构相关，但因果关系尚未建立，主要是由于无法操纵全局RT程序。我们表明，RIF 1的损失导致几乎完全消除的RT程序，通过增加个体细胞之间的异质性。RT变化与染色质修饰和基因组区室化的广泛改变相结合。RIF 1的条件性缺失导致组蛋白修饰的复制依赖性破坏和基因组结构的改变。这些影响被放大与连续周期的改变RT。这些结果支持模型中，染色质复制的时机，从而组装在维持全球表观遗传状态中起着关键作用。由RIF 1控制的复制时间有助于决定染色质状态和3D基因组组织。
The temporal order of DNA replication (replication timing; RT) is correlated with chromatin modifications and 3D genome architecture, however causal links have not been established, largely due to an inability to manipulate the global RT program. We show that loss of RIF1 causes near complete elimination of the RT program by increasing heterogeneity between individual cells. RT changes are coupled with widespread alterations in chromatin modifications and genome compartmentalization. Conditional depletion of RIF1 causes replication-dependent disruption of histone modifications and alterations in genome architecture. These effects were magnified with successive cycles of altered RT. These results support models in which the timing of chromatin replication and thus assembly plays a key role in maintaining the global epigenetic state. Replication timing controlled by RIF1 helps to dictate chromatin state and 3D genome organization.
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DOI：
10.1093/bioinformatics/btq033
发表时间：
2010-03-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Quinlan AR;Hall IM
通讯作者：
Hall IM
影响因子：
16
作者：
Reverón-Gómez N;González-Aguilera C;Stewart-Morgan KR;Petryk N;Flury V;Graziano S;Johansen JV;Jakobsen JS;Alabert C;Groth A
通讯作者：
Groth A
影响因子：
9.8
作者：
Seller CA;O'Farrell PH
通讯作者：
O'Farrell PH
影响因子：
16
作者：
Foti R;Gnan S;Cornacchia D;Dileep V;Bulut-Karslioglu A;Diehl S;Buness A;Klein FA;Huber W;Johnstone E;Loos R;Bertone P;Gilbert DM;Manke T;Jenuwein T;Buonomo SC
通讯作者：
Buonomo SC
DOI：
10.1007/978-981-10-6955-0_12
发表时间：
2017-01-01
期刊：
DNA REPLICATION: FROM OLD PRINCIPLES TO NEW DISCOVERIES
影响因子：
--
作者：
Buonomo, Sara B. C.
通讯作者：
Buonomo, Sara B. C.