Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models.
Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models.
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DOI：
10.1038/tp.2014.31
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发表时间：
2014-05-13
影响因子：
6.8
通讯作者：
Baune BT
中科院分区：
文献类型：
--
作者：
Harrison EL;Baune BT
童年的逆境改变了日后精神疾病的易感性。那些有精神疾病和早期逆境史的人与没有这种历史的人相比，表现出更高的治疗抵抗率。调节早期压力对神经生物学的影响可能有助于防止某些情况下精神疾病的发展，同时减轻那些患有精神疾病的人对治疗的抵抗程度。这篇综述的目的是批判性地评估行为，环境和药物干预的能力，以调节动物模型中的早期应激引起的神经生物学变化。对数据库进行了系统检索，以查找与本综述相关的文献。早期的逆境被定义为由于操纵母婴关系而产生的压力。分析仅限于动物模型，以表征给定的干预如何改变早期应激诱导的特定神经生物学变化。由于早期压力而引起的神经生物学的各种变化都是可以干预的。童年时期的行为干预、青春期的锻炼以及终生服用表观遗传修饰药物似乎可以最好地调节童年逆境引起的细胞和行为改变。其他药物疗法，如内源性大麻素系统调节剂、抗炎药和抗抑郁药，也可以影响这些由早期压力引起的神经生物学和行为变化，尽管目前的研究结果不太一致，需要进一步调查。在可能转化为临床实践之前，需要进一步研究行为干预，运动和表观遗传修饰药物对人类研究中儿童期压力后发生的变化的影响。
Childhood adversity alters the predisposition to psychiatric disorders later in life. Those with psychiatric conditions and a history of early adversity exhibit a higher incidence of treatment resistance compared with individuals with no such history. Modulation of the influence early stress exerts over neurobiology may help to prevent the development of psychiatric disorders in some cases, while attenuating the extent of treatment resistance in those with established psychiatric disorders. This review aims to critically evaluate the ability of behavioural, environmental and pharmacologic interventions to modulate neurobiological changes induced by early stress in animal models. Databases were systematically searched to locate literature relevant to this review. Early adversity was defined as stress that resulted from manipulation of the mother–infant relationship. Analysis was restricted to animal models to enable characterisation of how a given intervention altered specific neurobiological changes induced by early stress. A wide variety of changes in neurobiology due to early stress are amenable to intervention. Behavioural interventions in childhood, exercise in adolescence and administration of epigenetic-modifying drugs throughout life appear to best modulate cellar and behavioural alterations induced by childhood adversity. Other pharmacotherapies, such as endocannabinoid system modulators, anti-inflammatories and antidepressants can also influence these neurobiological and behavioural changes that result from early stress, although findings are less consistent at present and require further investigation. Further work is required to examine the influence that behavioural interventions, exercise and epigenetic-modifying drugs exert over alterations that occur following childhood stress in human studies, before possible translational into clinical practice is possible.
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影响因子：
11
作者：
Bessa, J. M.;Ferreira, D.;Sousa, N.
通讯作者：
Sousa, N.
影响因子：
15.1
作者：
Avitsur, Ronit;Sheridan, John F.
通讯作者：
Sheridan, John F.
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3.2
作者：
Cohen, H.;Kaplan, Z.;Zohar, J.
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3.7
作者：
Aisa, Barbara;Tordera, Rosa;Ramirez, Maria J.
通讯作者：
Ramirez, Maria J.
影响因子：
4.7
作者：
Eyre HA;Papps E;Baune BT
通讯作者：
Baune BT