Epigenetic basis of cancer health disparities: Looking beyond genetic differences.
Epigenetic basis of cancer health disparities: Looking beyond genetic differences.
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DOI：
10.1016/j.bbcan.2017.01.001
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Singh AP
中科院分区：
文献类型：
--
作者：
Ahmad A;Azim S;Zubair H;Khan MA;Singh S;Carter JE;Rocconi RP;Singh AP
尽管在各个层面都做出了努力，但癌症患者的种族健康差异仍然存在。这些发病率和/或临床结果的不平等只能用多种因素来解释，遗传基础是其中之一。一些研究提供了令人信服的证据，支持癌症相关基因的表观遗传调控，这导致转录组和蛋白质组的差异，并可能与某些种族/民族的个体易患早期或更具侵袭性的癌症有关。最近的技术进步和快速分析全基因组的能力有助于这些努力，并且由于它们相对容易检测，甲基化事件比乙酰化事件在人群中更容易表征。研究一组预先确定的差异表观遗传调控基因的早期趋势为更公正的筛选铺平了道路。这篇综述总结了我们目前对表观遗传事件的理解，这些事件与癌症发病率和死亡率的种族差异有关。更好地理解种族多样性的表观遗传学为设计和执行针对人类表观基因组的新策略以减少差异差距提供了希望。
Despite efforts at various levels, racial health disparities still exist in cancer patients. These inequalities in incidence and/or clinical outcome can only be explained by a multitude of factors, with genetic basis being one of them. Several investigations have provided convincing evidence to support epigenetic regulation of cancer-associated genes, which results in the differential transcriptome and proteome, and may be linked to a pre-disposition of individuals of certain race/ethnicity to early or more aggressive cancers. Recent technological advancements and the ability to quickly analyze whole genome have aided in these efforts, and owing to their relatively easy detection, methylation events are much well-characterized, than the acetylation events, across human populations. The early trend of investigating a pre-determined set of genes for differential epigenetic regulation is paving way for more unbiased screening. This review summarizes our current understanding of the epigenetic events that have been tied to the racial differences in cancer incidence and mortality. A better understanding of the epigenetics of racial diversity holds promise for the design and execution of novel strategies targeting the human epigenome for reducing the disparity gaps.
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影响因子：
5.7
作者：
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DOI：
10.2741/4515
发表时间：
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期刊：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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作者：
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