Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
复制标题
DOI：
10.1371/journal.pone.0020559
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Dong X
中科院分区：
文献类型：
--
作者：
Patel KN;Liu Q;Meeker S;Undem BJ;Dong X
瘙痒是一个重要的临床问题，其分子基础尚不清楚。最近的工作已经开始在分子水平上识别有助于检测瘙痒的基因。在这里，我们表明，Pirt，已知通过调制瞬时受体电位香草酸1（TRPV 1）通道在感知疼痛中发挥重要作用，也是必要的适当的瘙痒感觉。Pirt−/−小鼠对各种致痒化合物或致痒剂表现出细胞和行为反应的缺陷。Pirt有助于组胺能和非组胺能瘙痒，并且关键地，参与TRPV 1依赖性和非依赖性瘙痒形式。我们的研究结果表明，Pirt的功能通过TRPV 1调节延伸到伤害感受之外，作为几种瘙痒信号通路的关键组成部分。
Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt−/− mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways.
登录
查看更多内容
影响因子：
4.8
作者：
Chung, MK;Lee, H;Caterina, MJ
通讯作者：
Caterina, MJ
影响因子：
3.6
作者：
Akiyama, Tasuku;Carstens, Mirela Iodi;Carstens, Earl
通讯作者：
Carstens, Earl
影响因子：
2.7
作者：
Katugampola, R;Church, MK;Clough, GF
通讯作者：
Clough, GF
影响因子：
3.5
作者：
Hashimoto, Y;Arai, I;Nakaike, S
通讯作者：
Nakaike, S
DOI：
10.1073/pnas.0705924104
发表时间：
2007-08-14
影响因子：
11.1
作者：
McNamara, Colleen R.;Mandel-Brehm, Josh;Fanger, Christopher M.
通讯作者：
Fanger, Christopher M.