Elliptical localization with pulsed second-order fields (ECLIPSE) for robust lipid suppression in proton MRSI.
Elliptical localization with pulsed second-order fields (ECLIPSE) for robust lipid suppression in proton MRSI.
复制标题
DOI：
10.1002/nbm.3949
复制
发表时间：
2018-09
影响因子：
2.9
通讯作者：
Nixon TW
中科院分区：
文献类型：
--
作者：
de Graaf RA;Brown PB;De Feyter HM;McIntyre S;Nixon TW
质子磁共振波谱成像(MRSI)在健康和病理人脑的代谢图谱方面具有巨大的临床潜力。不幸的是，这一承诺尚未完全实现，因为与磁场不均匀导致的光谱质量不足、射频发射功率不足和脂质抑制不完全相关的许多技术挑战。在此，我们提出了一种稳健的、新颖的1H磁共振成像中抑制脂质的方法。该方法基于脉冲二阶球谐(SH)磁场对椭圆形感兴趣区的二维空间定位。设计和建造了一个专用的高幅度二阶SH梯度装置，其中包含用于产生Z2、X2Y2和XY磁场的线圈。通过仿真和体模核磁共振实验验证了该方法的原理，并对化学位移的表现形式进行了说明。活体人脑的1H MRSI显示出高质量的1H MRSI，并对颅外脂肪有很强的抑制作用。该方法允许大范围的内、外体积选择或抑制，可应用于磁共振成像、缩小视野磁共振成像和单体积磁共振成像。提出了一种基于脉冲二次球谐(SH)磁场对椭圆形感兴趣区域进行空间定位的1H磁共振成像中抑制脂质的新方法。设计并制作了一套包含产生Z2、X2Y2和XY磁场的线圈的高幅度二阶SH梯度装置。模拟和模拟结果验证了该方法的原理，并说明了化学位移的表现形式。活体人脑的1H MRSI显示出高质量的1H MRSI，并对颅外脂肪有很强的抑制作用。
Proton MR spectroscopic imaging (MRSI) has great clinical potential for metabolic mapping of the healthy and pathological human brain. Unfortunately, the promise has not yet been fully achieved due to numerous technical challenges related to insufficient spectral quality caused by magnetic field inhomogeneity, insufficient RF transmit power and incomplete lipid suppression. Here a robust, novel method for lipid suppression in 1H MRSI is presented. The method is based on 2D spatial localization of an elliptical region-of-interest using pulsed second-order spherical harmonics (SH) magnetic fields. A dedicated, high-amplitude second-order SH gradient setup was designed and constructed, containing coils to generate Z2, X2Y2 and XY magnetic fields. Simulations and phantom MRI results are used to demonstrate the principles of the method and illustrate the manifestation of chemical shift displacement. 1H MRSI on human brain in vivo demonstrate high-quality 1H MRSI with robust suppression of extracranial lipids. The method allows a wide range of inner or outer volume selection or suppression and should find application in MRSI, reduced field-of-view MRI and single-volume MRS. A novel method for lipid suppression in 1H MRSI is presented based on spatial localization of an elliptical region-of-interest using pulsed second-order spherical harmonics (SH) magnetic fields. A high-amplitude second-order SH gradient setup was designed and constructed, containing coils to generate Z2, X2Y2 and XY magnetic fields. Simulations and phantom results demonstrate the principles of the method and illustrate the manifestation of chemical shift displacement. 1H MRSI on human brain in vivo demonstrates high-quality 1H MRSI with robust suppression of extracranial lipids.
登录
查看更多内容
影响因子：
5.6
作者：
Pan JW;Duckrow RB;Gerrard J;Ong C;Hirsch LJ;Resor SR Jr;Zhang Y;Petroff O;Spencer S;Hetherington HP;Spencer DD
通讯作者：
Spencer DD
影响因子：
3.3
作者：
KLOSE, U
通讯作者：
KLOSE, U
影响因子：
3.3
作者：
Boer, Vincent O.;van de Lindt, Tessa;Klomp, Dennis W. J.
通讯作者：
Klomp, Dennis W. J.
影响因子：
3.3
作者：
Haupt, CI;Schuff, N;Maudsley, AA
通讯作者：
Maudsley, AA
影响因子：
3.3
作者：
Ordidge, RJ;Wylezinska, M;Franconi, F
通讯作者：
Franconi, F