7T MR spectroscopic imaging in the localization of surgical epilepsy.
7T MR spectroscopic imaging in the localization of surgical epilepsy.
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DOI：
10.1111/epi.12322
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发表时间：
2013-09
期刊：
影响因子：
5.6
通讯作者：
Spencer DD
中科院分区：
文献类型：
--
作者：
Pan JW;Duckrow RB;Gerrard J;Ong C;Hirsch LJ;Resor SR Jr;Zhang Y;Petroff O;Spencer S;Hetherington HP;Spencer DD
随着手术治疗定位相关癫痫的成功，准确的癫痫发作定位仍然很重要。虽然磁共振（MR）光谱在内侧颞叶癫痫的早期研究中取得了成功，但评估其在更广泛的定位相关癫痫中的应用的研究较少。随着超高场磁共振的信噪比的提高，我们报告了在3.5年的时间里对25名手术治疗患者使用高分辨率7T磁共振光谱成像（MRSI）的研究。如果MRSI研究的区域包括手术切除区域，则将患者纳入本分析。MRSI异常区域与手术切除之间的一致性被分为三组（完全、部分或不一致），结果被国际抗癫痫联盟（ILAE）分为I-III组和IV-VI组。磁共振成像以二维（2D）或三维（3D）编码的重复时间/回声时间1.5 s/40 msec进行，以检测单线n -乙酰天冬氨酸（NAA）、肌酸（Cr）和胆碱，NAA/Cr异常通过校正灰质组织含量来确定。mri检测的异常与手术切除区域之间的一致性与预后显著相关：如果切除的组织代谢异常，预后更好。14例完全切除最严重代谢异常区域的患者预后良好，其中5例需要颅内脑电图（EEG）分析，而未完全切除最严重代谢异常的患者只有3/11预后良好（p < 0.001）。这与以代谢功能障碍为特征的癫痫发作区是一致的，并表明高分辨率磁共振成像可以帮助确定这些区域以预测结果。
With the success that surgical approaches can provide for localization-related epilepsy, accurate seizure localization remains important. Although magnetic resonance (MR) spectroscopy has had success in earlier studies in medial temporal lobe epilepsy, there have been fewer studies evaluating its use in a broader range of localization-related epilepsy. With improvements in signal-to-noise with ultra-high field MR, we report on the use of high resolution 7T MR spectroscopic imaging (MRSI) in 25 surgically treated patients studied over a 3.5-year period. Patients were included in this analysis if the region of MRSI study included the surgical resection region. Concordance between region of MRSI abnormalities and of surgical resection was classified into three groups (complete, partial, or no agreement) and outcome was dichotomized by International League Against Epilepsy (ILAE) I–III and IV–VI groups. MRSI was performed with repetition time/echo time 1.5 s/40 msec in two-dimensional (2D) or three-dimensional (3D) encoding for robust detection of singlets N-acetyl aspartate (NAA), creatine (Cr), and choline with abnormalities in NAA/Cr determined with correction for tissue content of gray matter. The concordance between MRSI-determined abnormality and surgical resection region was significantly related to outcome: Outcome was better if the resected tissue was metabolically abnormal. All 14 patients with complete resection of the region with the most severe metabolic abnormality had good outcome, including five requiring intracranial electroencephalography (EEG) analysis, whereas only 3/11 without complete resection of the most severe metabolic abnormality had good outcome (p < 0.001). This is consistent with the seizure-onset zone being characterized by metabolic dysfunction and suggests that high resolution MRSI can help define these regions for the purposes of outcome prediction.
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MR光谱成像中癫痫中的代谢网络。
影响因子：
3.5
作者：
Pan JW;Spencer DD;Kuzniecky R;Duckrow RB;Hetherington H;Spencer SS
通讯作者：
Spencer SS
DOI：
10.1007/s10334-010-0220-0
发表时间：
2010-12-01
影响因子：
2.3
作者：
Hale, Joanne R.;Brookes, Matthew J.;Morris, Peter G.
通讯作者：
Morris, Peter G.
影响因子：
6
作者：
Mueller, Susanne G.;Ebel, Andreas;Laxer, Kenneth D.
通讯作者：
Laxer, Kenneth D.
影响因子：
2.2
作者：
Maudsley, Andrew A.;Domenig, Claudia;Ramsay, R. Eugene;Bowen, Brian C.
通讯作者：
Bowen, Brian C.
影响因子：
2.8
作者：
Harada, M;Miyoshi, H;Uno, M
通讯作者：
Uno, M