MERS transmission and risk factors: a systematic review.
MERS transmission and risk factors: a systematic review.
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DOI：
10.1186/s12889-018-5484-8
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发表时间：
2018-05-02
影响因子：
4.5
通讯作者：
Park JE
中科院分区：
文献类型：
--
作者：
Park JE;Jung S;Kim A;Park JE
自2012年首次报道中东呼吸综合征（MERS）感染以来，许多研究分析了其传播性和严重程度。然而，这些研究的方法和结果各不相同，并且没有对MERS进行系统回顾。本文综述了MERS的特点及相关危险因素。我们检索了国际数据库（PubMed, ScienceDirect, Cochrane）和韩国数据库（DBpia， KISS）中使用“MERS”和“中东呼吸综合征”这两个术语的英语或韩语文章。仅分析了20名受试者的人类研究，以排除低代表性的研究。包括有关中东呼吸综合征传播性和严重程度信息的流行病学研究以及包含中东呼吸综合征危险因素的研究。总共纳入了59项研究。来自沙特阿拉伯的大多数研究报告的死亡率（22-69.2%）高于韩国（20.4%）。沙特阿拉伯的R0值除一项研究外均< 1，而韩国的R0值在前期为2.5-8.09，后期降至< 1。沙特潜伏期为4.5-5.2天，韩国潜伏期为6-7.8天。发病至确诊时间为4 ~ 10天，住院时间为2.9 ~ 5.3天，死亡时间为11 ~ 17天，出院时间为14 ~ 20天。年龄和伴随疾病是与MERS感染、严重程度和死亡率相关的最常见因素。MERS的传播力和严重程度因疫情地区和患者特征而异。进一步评估中东呼吸综合征风险的研究应考虑这些因素。
Since Middle East respiratory syndrome (MERS) infection was first reported in 2012, many studies have analysed its transmissibility and severity. However, the methodology and results of these studies have varied, and there has been no systematic review of MERS. This study reviews the characteristics and associated risk factors of MERS. We searched international (PubMed, ScienceDirect, Cochrane) and Korean databases (DBpia, KISS) for English- or Korean-language articles using the terms “MERS” and “Middle East respiratory syndrome”. Only human studies with > 20 participants were analysed to exclude studies with low representation. Epidemiologic studies with information on transmissibility and severity of MERS as well as studies containing MERS risk factors were included. A total of 59 studies were included. Most studies from Saudi Arabia reported higher mortality (22–69.2%) than those from South Korea (20.4%). While the R0 value in Saudi Arabia was < 1 in all but one study, in South Korea, the R0 value was 2.5–8.09 in the early stage and decreased to < 1 in the later stage. The incubation period was 4.5–5.2 days in Saudi Arabia and 6–7.8 days in South Korea. Duration from onset was 4–10 days to confirmation, 2.9–5.3 days to hospitalization, 11–17 days to death, and 14–20 days to discharge. Older age and concomitant disease were the most common factors related to MERS infection, severity, and mortality. The transmissibility and severity of MERS differed by outbreak region and patient characteristics. Further studies assessing the risk of MERS should consider these factors.
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DOI：
10.1186/s13054-016-1303-8
发表时间：
2016-05-07
期刊：
Critical care (London, England)
影响因子：
--
作者：
Almekhlafi GA;Albarrak MM;Mandourah Y;Hassan S;Alwan A;Abudayah A;Altayyar S;Mustafa M;Aldaghestani T;Alghamedi A;Talag A;Malik MK;Omrani AS;Sakr Y
通讯作者：
Sakr Y
影响因子：
56.3
作者：
Cauchemez, Simon;Fraser, Christophe;Van Kerkhove, Maria D.;Donnelly, Christi A.;Riley, Steven;Rambaut, Andrew;Enouf, Vincent;van der Werf, Sylvie;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.
影响因子：
11.8
作者：
Alenazi, Thamer H.;Al Arbash, Hussain;Balkhy, Hanan H.
通讯作者：
Balkhy, Hanan H.
影响因子：
4.4
作者：
Eifan SA;Nour I;Hanif A;Zamzam AMM;AlJohani SM
通讯作者：
AlJohani SM
影响因子：
11.8
作者：
Assiri A;Abedi GR;Bin Saeed AA;Abdalla MA;al-Masry M;Choudhry AJ;Lu X;Erdman DD;Tatti K;Binder AM;Rudd J;Tokars J;Miao C;Alarbash H;Nooh R;Pallansch M;Gerber SI;Watson JT
通讯作者：
Watson JT