Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration.
Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration.
复制标题
肌球蛋白II电动机和F-肌动蛋白动力学驱动中心神经胶质引导的神经元迁移期间中心体和SOMA的协调运动。
DOI：
10.1016/j.neuron.2009.05.028
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发表时间：
2009-07-16
期刊：
影响因子：
16.2
通讯作者：
Hatten, Mary E.
中科院分区：
文献类型：
--
作者：
Solecki, David J.;Trivedi, Niraj;Govek, Eve-Ellen;Kerekes, Ryan A.;Gleason, Shaun S.;Hatten, Mary E.
Lamination of cortical regions of the vertebrate brain depends on glial-guided neuronal migration. The conserved polarity protein Par6α localizes to the centrosome and coordinates forward movement of the centrosome and soma in migrating neurons. The cytoskeletal components that produce this unique form of cell polarity and their relationship to polarity signaling cascades are unknown. We show that F-actin and Myosin II motors are enriched in the neuronal leading process and Myosin II activity is necessary for leading process actin dynamics. Inhibition of Myosin II decreased the speed of centrosome and somal movement, while Myosin II activation increased coordinated movement. Ectopic expression or silencing of Par6α inhibited Myosin II motors by decreasing Myosin Light Chain phosphorylation. These findings suggest leading process Myosin II may function to “pull” the centrosome and soma forward during glial-guided migration by a mechanism involving the conserved polarity protein Par6α.
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DOI：
10.1083/jcb.100.2.384
发表时间：
1985-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hatten ME
通讯作者：
Hatten ME
影响因子：
56.9
作者：
Hu, Ke;Ji, Lin;Waterman-Storer, Clare M.
通讯作者：
Waterman-Storer, Clare M.
影响因子：
9.2
作者：
Garces, JA;Clark, IB;Vallee, RB
通讯作者：
Vallee, RB
影响因子：
9.2
作者：
Cramer, LP
通讯作者：
Cramer, LP
DOI：
10.1083/jcb.200810041
发表时间：
2009-02-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Doyle AD;Wang FW;Matsumoto K;Yamada KM
通讯作者：
Yamada KM