Body mass index and survival of patients with lymphoma.
Body mass index and survival of patients with lymphoma.
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DOI：
10.1080/10428194.2021.1929956
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发表时间：
2021-11
影响因子：
2.6
通讯作者：
Morton LM
中科院分区：
文献类型：
--
作者：
Chihara D;Larson MC;Robinson DP;Thompson CA;Maurer MJ;Casulo C;Pophali P;Link BK;Habermann TM;Feldman AL;Flowers CR;Cerhan JR;Morton LM
身体质量指数（BMI）对淋巴瘤患者生存的影响仍有争议。我们利用2002-2015年在SPORE分子流行病学资源登记的淋巴瘤患者的前瞻性队列来评估诊断前BMI、诊断时BMI以及BMI随时间变化与淋巴瘤特异性生存（LSS）的关系。共纳入4009例淋巴瘤患者，其中弥漫大b细胞淋巴瘤（DLBCL） 670例，滤泡性淋巴瘤（FL） 689例，慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL） 1018例，其他1632例。诊断前肥胖的FL患者诊断后LSS明显缩短（HR: 3.02, 95%CI: 1.43-6.41, p=0.004），诊断后至3年随访时BMI增加≥5%的FL患者诊断后LSS明显缩短（HR: 3.53, 95%CI: 1.22-10.2, p=0.020）。相比之下，诊断前或诊断时的肥胖与DLBCL和CLL/SLL的LSS无关。FL患者诊断后体重控制的影响值得探讨。
The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002–2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4,009 lymphoma patients (670 diffuse large B-cell lymphoma [DLBCL], 689 follicular lymphoma [FL], 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma [CLL/SLL], 1,632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43–6.41, p=0.004) and for those with a ≥5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22–10.2, p=0.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation.
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DOI：
10.1158/1055-9965.epi-14-1355
发表时间：
2015-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kane E;Skibola CF;Bracci PM;Cerhan JR;Costas L;Smedby KE;Holly EA;Maynadié M;Novak AJ;Lightfoot TJ;Ansell SM;Smith AG;Liebow M;Melbye M;Morton L;de Sanjosé S;Slager SL;Wang SS;Zhang Y;Zheng T;Roman E
通讯作者：
Roman E
影响因子：
3.5
作者：
Weiss L;Melchardt T;Egle A;Hopfinger G;Hackl H;Greil R;Barth J;Rummel M
通讯作者：
Rummel M
影响因子：
12.8
作者：
Sonbol, Mohamad B.;Maurer, Matthew J.;Stenson, Mary J.;Allmer, Cristine;LaPlant, Betsy R.;Weiner, George J.;Macon, William R.;Cerhan, James R.;Witzig, Thomas E.;Gupta, Mamta
通讯作者：
Gupta, Mamta
影响因子：
45.3
作者：
Carson, Kenneth R.;Bartlett, Nancy L.;Colditz, Graham A.
通讯作者：
Colditz, Graham A.
影响因子：
254.7
作者：
Rock, Cheryl L.;Doyle, Colleen;Gansler, Ted
通讯作者：
Gansler, Ted