Preventing bacterial disease in poultry in the post-antibiotic era: a case for innate immunity modulation as an alternative to antibiotic use.
Preventing bacterial disease in poultry in the post-antibiotic era: a case for innate immunity modulation as an alternative to antibiotic use.
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DOI：
10.3389/fimmu.2023.1205869
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
抗生素在家禽业中的广泛使用导致了抗药性细菌的出现，这对人类和动物构成了重大的健康风险。这些公共卫生问题导致立法限制动物使用抗生素，从而推动了寻找控制和治疗细菌感染的替代策略的需求。使用免疫刺激化合物调节禽类先天免疫系统提供了一种有前景的解决方案，以增强家禽对广泛的细菌感染的免疫应答，而没有产生抗生素抗性的风险。已经研究了一系列免疫调节化合物对家禽性能和免疫应答的影响。然而，需要进一步的研究来确定能够控制细菌感染而不会对鸟类性能产生不利影响的化合物。确定这些化合物与家禽疫苗联合使用的安全性和有效性也至关重要。本文综述了各种免疫调节剂，已知增强对禽细菌病原体的先天免疫鸡，并描述了所涉及的机制。
The widespread use of antibiotics in the poultry industry has led to the emergence of antibiotic-resistant bacteria, which pose a significant health risk to humans and animals. These public health concerns, which have led to legislation limiting antibiotic use in animals, drive the need to find alternative strategies for controlling and treating bacterial infections. Modulation of the avian innate immune system using immunostimulatory compounds provides a promising solution to enhance poultry immune responses to a broad range of bacterial infections without the risk of generating antibiotic resistance. An array of immunomodulatory compounds have been investigated for their impact on poultry performance and immune responses. However, further research is required to identify compounds capable of controlling bacterial infections without detrimentally affecting bird performance. It is also crucial to determine the safety and effectiveness of these compounds in conjunction with poultry vaccines. This review provides an overview of the various immune modulators known to enhance innate immunity against avian bacterial pathogens in chickens, and describes the mechanisms involved.
影响因子：
4
作者：
Rodrigues DR;Wilson KM;Bielke LR
通讯作者：
Bielke LR
DOI：
10.3390/ani11061742
发表时间：
2021-06-10
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
Chou PC;Lin PC;Wu SW;Wang CK;Chung TK;Walzem RL;Lai LS;Chen SE
通讯作者：
Chen SE