Proper Immune Response Depends on Early Exposure to Gut Microbiota in Broiler Chicks.
Proper Immune Response Depends on Early Exposure to Gut Microbiota in Broiler Chicks.
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DOI：
10.3389/fphys.2021.758183
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发表时间：
2021
影响因子：
4
通讯作者：
Bielke LR
中科院分区：
文献类型：
--
作者：
Rodrigues DR;Wilson KM;Bielke LR
早期肠道微生物群的连续变化伴随着粘膜免疫系统的发育、扩张和教育而发生。虽然研究人员一直专注于了解微生物群与免疫功能之间的联系，但肠道先锋微生物群与鸟类免疫系统之间共生关系的许多重要细节仍有待发现。本研究旨在了解不同早期肠道定植菌对雏鸡先天性和适应性免疫过程的影响，并进一步鉴定肠道组织中表达的免疫相关蛋白。为了实现这一目标，我们进行了两个非致病性肠杆菌科分离株和乳酸菌（L）的卵内应用，以确定其对孵化当天（DOH）和10日龄肉鸡肠道蛋白质组谱的影响。结果表明，L处理雏鸡具有与天然免疫系统和适应性免疫系统的激活和平衡有关的生物学功能。与此同时，暴露于肠杆菌的鸟类呈现出免疫机制失调或与免疫发育相关的过程下调。这些发现表明，适当的免疫功能取决于特定的肠道微生物群暴露，其中产前益生菌应用可能有利于鸡的免疫功能的适当编程。
The successional changes in the early intestinal microbiota occur concomitantly with the development, expansion, and education of the mucosal immune system. Although great attention of researchers has been focused on understanding the linkage between microbiota and immune functions, many essential details of the symbiotic relationship between the intestinal pioneer microbiota and the avian immune system remain to be discovered. This study was conducted to understand the impact of different early life intestinal colonizers on innate and adaptive immune processes in chicks and further identify immune-associated proteins expressed in the intestinal tissue. To accomplish it, we performed an in ovo application of two apathogenic Enterobacteriaceae isolates and lactic acid bacteria (L) to determine their influences on the intestinal proteome profile of broilers at the day of hatch (DOH) and at 10 days old. The results indicated that there were predicted biological functions of L-treated chicks associated with the activation and balanced function of the innate and adaptive immune systems. At the same time, the Enterobacteriaceae-exposed birds presented dysregulated immunological mechanisms or downregulated processes related to immune development. Those findings suggested that a proper immune function was dependent on specific gut microbiota exposure, in which the prenatal probiotic application may have favored the fitting programming of immune functions in chicks.
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影响因子：
64.5
作者：
Chung H;Pamp SJ;Hill JA;Surana NK;Edelman SM;Troy EB;Reading NC;Villablanca EJ;Wang S;Mora JR;Umesaki Y;Mathis D;Benoist C;Relman DA;Kasper DL
通讯作者：
Kasper DL
影响因子：
2.9
作者：
Kalenik, Barbara Malgorzata;Gora-Sochacka, Anna;Sirko, Agnieszka
通讯作者：
Sirko, Agnieszka
影响因子：
3.2
作者：
Ballou AL;Ali RA;Mendoza MA;Ellis JC;Hassan HM;Croom WJ;Koci MD
通讯作者：
Koci MD
影响因子：
9.9
作者：
Geyer PE;Holdt LM;Teupser D;Mann M
通讯作者：
Mann M
将盲肠内容物给予孵化蛋后肉鸡肠道微生物群发育的时间过程。
影响因子：
2.7
作者：
Donaldson EE;Stanley D;Hughes RJ;Moore RJ
通讯作者：
Moore RJ