Endocrine crosstalk between muscle and bone.
Endocrine crosstalk between muscle and bone.
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DOI：
10.1007/s11914-014-0209-0
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发表时间：
2014-06
影响因子：
4.3
通讯作者：
Johnson, Mark L.
中科院分区：
文献类型：
--
作者：
Brotto, Marco;Johnson, Mark L.
肌肉骨骼系统是由骨骼、骨骼肌、肌腱、韧带、软骨、关节和其他结缔组织组成的复杂器官，它们在物理和机械上相互作用，为动物和人类提供基本的运动能力。毫无疑问，这种机械相互作用对于脊椎动物甚至具有基本肌肉骨骼系统的无脊椎动物（如鱼类）中观察到的许多不同形状和形式至关重要。从历史的角度来看，肌肉骨骼发育的力学理论对我们对生物学的理解产生了巨大的影响，因为这些关系是清晰和明显的。肉眼甚至显微镜都看不到的是肌肉骨骼系统中各个参与者之间的生化相互作用。直到最近几年，我们才开始意识到，除了肌肉和骨骼的这种机械耦合之外，这两种组织通过串扰信号机制在更高水平上发挥作用，这对伴随组织的功能很重要。我们的简要回顾试图提出这些新概念的一些关键概念，并概述了肌肉和骨骼作为分泌/内分泌器官，相互遗传和组织相互作用的证据，串扰的病理生理学例子，以及这一有前途的研究领域的令人兴奋的新方向，旨在了解这2个密切相关的组织的生化/分子耦合。
The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedly essential for much of the diverse shape and forms observed in vertebrates and even in invertebrates with rudimentary musculoskeletal systems such as fish. It makes sense from a historical point of view that the mechanical theories of musculoskeletal development have had tremendous influence of our understanding of biology, because these relationships are clear and palpable. Less visible to the naked eye or even to the microscope is the biochemical interaction among the individual players of the musculoskeletal system. It was only in recent years that we have begun to appreciate that beyond this mechanical coupling of muscle and bones, these 2 tissues function at a higher level through crosstalk signaling mechanisms that are important for the function of the concomitant tissue. Our brief review attempts to present some of the key concepts of these new concepts and is outline to present muscles and bones as secretory/endocrine organs, the evidence for mutual genetic and tissue interactions, pathophysiological examples of crosstalk, and the exciting new directions for this promising field of research aimed at understanding the biochemical/molecular coupling of these 2 intimately associated tissues.
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影响因子：
2.9
作者：
Cheng Y;Rachagani S;Cánovas A;Mayes MS;Tait RG Jr;Dekkers JC;Reecy JM
通讯作者：
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影响因子：
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作者：
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DOI：
10.1302/0301-620x.82b7.10482
发表时间：
2000-09-01
影响因子：
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作者：
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通讯作者：
Smith, RM
影响因子：
2.9
作者：
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通讯作者：
Schiaffino, S