Recent tuberculosis advances in Latin America.
Recent tuberculosis advances in Latin America.
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DOI：
10.1097/00001432-200410000-00003
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发表时间：
2004-10
影响因子：
3.9
通讯作者：
Evans C
中科院分区：
文献类型：
--
作者：
Pelly T;Moore DA;Gilman R;Evans C
Tuberculosis kills more people than any other infection. Despite advances in diagnostic methods and greater understanding of the reasons for treatment failure, tuberculosis remains common throughout Latin America. The impact of HIV and multidrug resistance on tuberculosis control has been enormous. HIV-positive patients may be at 10 times greater risk of multidrug resistant tuberculosis than HIV- negative patients. Hopefully, improved diagnostic techniques will allow more rapid diagnosis of tuberculosis and new colorimetric systems are being developed that will enable expedited drug-sensitivity testing. However, in alarming reports, only 58% of patients were treated with the recommended treatment regime in a Brazilian study, and dropout from treatment in parts of Bolivia was common. Many failings could be combated by rigorous education of patients and physicians. In an encouraging advance, multidrug resistant tuberculosis was successfully treated in a community-based programme, saving an estimated 90% of the cost of hospital-based treatment. An opportunity to identify treatment failure earlier is demonstrated by the finding that 2 months after the initiation of therapy, positive smears were found in only 3% of those whose treatment was successful, but 74% of those whose treatment failed. The importance of inexpensive and widely available drugs to treat HIV and multidrug resistant tuberculosis in Latin America is clear. The need for rapid, affordable tests for tuberculosis diagnosis, and for easy drug sensitivity testing is also evident. Finally, improving treatment success is achievable even in the resource poor setting.
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DOI：
10.1590/s0074-02762002000800027
发表时间：
2002-12-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Carvalho, Anna CC;Nunes, Zoelete B;Kritski, Afrânio L
通讯作者：
Kritski, Afrânio L
影响因子：
9.4
作者：
Ahmed, N;Caviedes, L;Hasnain, SE
通讯作者：
Hasnain, SE
影响因子：
4.2
作者：
Hadad, DJ;Palaci, M;Palhares, MCA
通讯作者：
Palhares, MCA
影响因子：
11.8
作者：
Campos PE;Suarez PG;Sanchez J;Zavala D;Arevalo J;Ticona E;Nolan CM;Hooton TM;Holmes KK
通讯作者：
Holmes KK
影响因子：
9.4
作者：
Caviedes, L;Delgado, J;Gilman, RH
通讯作者：
Gilman, RH