Quantitative analysis of neuronal response properties in primary and higher-order auditory cortical fields of awake house mice (Mus musculus).
Quantitative analysis of neuronal response properties in primary and higher-order auditory cortical fields of awake house mice (Mus musculus).
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DOI：
10.1111/ejn.12478
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Kurt S
中科院分区：
文献类型：
--
作者：
Joachimsthaler B;Uhlmann M;Miller F;Ehret G;Kurt S
由于其巨大的遗传潜力，小鼠（Mus musculus）已成为研究听觉和声音处理沿着听觉通路的流行模式物种。在这里，我们提出了第一个比较研究的代表性的神经元反应参数的音调在初级和高阶听觉皮层领域的清醒小鼠。我们量化了12个神经元的音调处理的特性，以估计字段之间的功能的相似性和差异，并讨论在小鼠的听觉皮层（AC）的功能是在清醒的猴子和猫相媲美。细胞外记录从1400个小集群的神经元皮层第III/IV层的主要领域AI（初级听觉领域）和AAF（前听觉领域），和高阶领域AII（第二听觉领域）和DP（背后场）。场特异性表现在自发活动、自发活动和诱发活动之间的相关性、音调反应潜伏期、频率调谐的锐度、时间反应模式（阶段性反应、阶段性-紧张性反应、紧张性反应和关闭反应的发生）以及特征频率（CF）和最佳频率（BF）之间的变化程度（CF-BF关系）。场的相似性被认为是CF和BF之间的显着相关性，V形的频率调谐曲线，类似的最小反应阈值和非单调率水平函数在大约三分之二的神经元。比较和定量分析表明，所测得的反应特性，在不同程度上，容易受到麻醉药的影响。因此，在清醒AC的神经元反应的研究是重要的，以建立足够的神经元数据和听觉感知和声学响应行为之间的关系。
Because of its great genetic potential, the mouse (Mus musculus) has become a popular model species for studies on hearing and sound processing along the auditory pathways. Here, we present the first comparative study on the representation of neuronal response parameters to tones in primary and higher-order auditory cortical fields of awake mice. We quantified 12 neuronal properties of tone processing in order to estimate similarities and differences of function between the fields, and to discuss how far auditory cortex (AC) function in the mouse is comparable to that in awake monkeys and cats. Extracellular recordings were made from 1400 small clusters of neurons from cortical layers III/IV in the primary fields AI (primary auditory field) and AAF (anterior auditory field), and the higher-order fields AII (second auditory field) and DP (dorsoposterior field). Field specificity was shown with regard to spontaneous activity, correlation between spontaneous and evoked activity, tone response latency, sharpness of frequency tuning, temporal response patterns (occurrence of phasic responses, phasic-tonic responses, tonic responses, and off-responses), and degree of variation between the characteristic frequency (CF) and the best frequency (BF) (CF–BF relationship). Field similarities were noted as significant correlations between CFs and BFs, V-shaped frequency tuning curves, similar minimum response thresholds and non-monotonic rate-level functions in approximately two-thirds of the neurons. Comparative and quantitative analyses showed that the measured response characteristics were, to various degrees, susceptible to influences of anesthetics. Therefore, studies of neuronal responses in the awake AC are important in order to establish adequate relationships between neuronal data and auditory perception and acoustic response behavior.
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影响因子：
25
作者：
Bandyopadhyay, Sharba;Shamma, Shihab A.;Kanold, Patrick O.
通讯作者：
Kanold, Patrick O.
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN
影响因子：
2.5
作者：
FROST, DO;CAVINESS, VS
通讯作者：
CAVINESS, VS
DOI：
10.1016/b978-0-12-374593-4.00013-9
发表时间：
2010-01-01
期刊：
HANDBOOK OF MAMMALIAN VOCALIZATION: AN INTEGRATIVE NEUROSCIENCE APPROACH
影响因子：
--
作者：
Ehret, Guenter;Kurt, Simone
通讯作者：
Kurt, Simone
核心听觉皮层的深度依赖性时间响应特性。
DOI：
10.1523/jneurosci.2863-11.2011
发表时间：
2011-09-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Christianson GB;Sahani M;Linden JF
通讯作者：
Linden JF