Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls.
Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls.
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海湾战争退伍军人与健康和有症状对照者血浆中枢神经系统蛋白自身抗体的性别差异。
DOI：
10.3390/brainsci11020148
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发表时间：
2021-01-23
期刊：
影响因子：
3.3
通讯作者：
Sullivan K
中科院分区：
文献类型：
--
作者：
Abou-Donia MB;Krengel MH;Lapadula ES;Zundel CG;LeClair J;Massaro J;Quinn E;Conboy LA;Kokkotou E;Nguyen DD;Abreu M;Klimas NG;Sullivan K
参加 1991 年海湾战争 (GW) 的退伍军人已患海湾战争疾病 (GWI) 近 30 年。这种疾病涉及多个身体系统，包括中枢神经系统 (CNS)。由于尚无客观的诊断生物标志物，GWI的诊断和治疗很困难。最近，我们报道了一种新开发的血液生物标志物，可将 GWI 与 GW 健康对照以及患有肠易激综合征 (IBS) 和肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS) 的症状对照区分开来。本研究旨在比较患有 GWI 的男性和女性之间这些生物标志物的水平，以及与健康的 GW 退伍军人和症状对照（IBS、ME/CFS）相比的性别特异性影响。结果显示，患有 GWI 的男性和女性在 10 种血浆自身抗体中的 2 种存在差异，其中男性的水平显着升高。与对照组相比，患有 GWI 的男性和女性在血浆中 10 种神经元和神经胶质蛋白生物标志物中的 8 种中表现出显着不同的自身抗体水平。总之，本研究探讨了使用血浆中枢神经系统蛋白自身抗体来区分患有 GWI 的男性和女性退伍军人以及其他健康和有症状的对照组的效用。
Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has not been an objective diagnostic biomarker. Recently, we reported on a newly developed blood biomarker that discriminates GWI from GW healthy controls, and symptomatic controls with irritable bowel syndrome (IBS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The present study was designed to compare levels of these biomarkers between men and women with GWI, as well as sex-specific effects in comparison to healthy GW veterans and symptomatic controls (IBS, ME/CFS). The results showed that men and women with GWI differ in 2 of 10 plasma autoantibodies, with men showing significantly elevated levels. Men and women with GWI showed significantly different levels of autoantibodies in 8 of 10 biomarkers to neuronal and glial proteins in plasma relative to controls. In summary, the present study addressed the utility of the use of plasma autoantibodies for CNS proteins to distinguish among both men and women veterans with GWI and other healthy and symptomatic control groups.
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影响因子：
3.4
作者：
Chao LL;Rothlind JC;Cardenas VA;Meyerhoff DJ;Weiner MW
通讯作者：
Weiner MW
影响因子：
3.4
作者：
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影响因子：
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作者：
Cherry, N;Creed, F;Macfarlane, GJ
通讯作者：
Macfarlane, GJ
影响因子：
3.3
作者：
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通讯作者：
Abou-Donia, MB
影响因子：
6.1
作者：
Abdel-Rahman, A;Shetty, AK;Abou-Donia, MB
通讯作者：
Abou-Donia, MB