Effects of 21 days of varenicline versus placebo on smoking behaviors and urges among non-treatment seeking smokers.
Effects of 21 days of varenicline versus placebo on smoking behaviors and urges among non-treatment seeking smokers.
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DOI：
10.1177/0269881112449397
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Strasser AA
中科院分区：
文献类型：
--
作者：
Ashare RL;Tang KZ;Mesaros AC;Blair IA;Leone F;Strasser AA
Varenicline promotes smoking cessation and reduces urges to smoke. However, the mechanisms associated with these effects and their time course are not well characterized. One mechanism may be extinction, but the duration of the current dosing protocol may not be sufficient. We examined the effect of extended pre-treatment with varenicline on smoking behavior among 17 non-treatment seeking adult smokers. Using a within-subjects, double-blind, placebo-controlled crossover design, participants received standard dosing of varenicline for 21 days, followed by a 14-day washout period and 21 days of placebo; order counterbalanced. Cigarettes per day (CPD), smoking topography, smoking urges (QSU), and side effects were assessed every three days. Biomarkers (e.g. nicotine metabolites) were collected on days 1, 7, and 21. There was a significant drug by time interaction indicating a reduction in CPD during varenicline phase (between days 10–21), but no reduction during placebo. Varenicline also led to reductions in nicotine metabolites and urges to smoke. Among this sample of non-treatment seeking smokers, varenicline significantly reduced smoking behavior. Results have important treatment implications because changes in CPD and craving did not occur until after the typical one-week run-up period. This suggests that a longer duration of pre-treatment may be beneficial for some smokers.
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影响因子：
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作者：
Franklin, Teresa;Wang, Ze;Suh, Jesse J.;Hazan, Rebecca;Cruz, Jeffrey;Li, Yin;Goldman, Marina;Detre, John A.;O'Brien, Charles P.;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
影响因子：
1.8
作者：
Rangiah K;Hwang WT;Mesaros C;Vachani A;Blair IA
通讯作者：
Blair IA
DOI：
10.1158/1055-9965.epi-09-0737
发表时间：
2009-12
期刊：
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影响因子：
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作者：
Muscat JE;Stellman SD;Caraballo RS;Richie JP Jr
通讯作者：
Richie JP Jr
影响因子：
4.4
作者：
Boyle, P;Gandini, S;Gray, N
通讯作者：
Gray, N
影响因子：
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作者：
Hajek, Peter;McRobbie, Hayden J.;Dhanji, Al-Rehan
通讯作者：
Dhanji, Al-Rehan