Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of population-based studies.
Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of population-based studies.
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DOI：
10.1186/1471-2458-7-212
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发表时间：
2007-08-17
影响因子：
4.5
通讯作者：
Victora CG
中科院分区：
文献类型：
--
作者：
Nazmi A;Victora CG
社会经济和种族/民族因素强烈影响心血管疾病的结局和风险因素。C反应蛋白(CRP)是一种非特异性炎症标志物，与心血管风险有关，了解其在人群中的分布可能有助于指导预防工作。根据社会经济和种族/民族因素对C反应蛋白水平进行了系统评价。检索Medline，直到2006年12月，以人群为基础的研究，检查成年人中关于社会经济地位(SEP)和/或种族/民族的指标的CRP水平。扫描了定位研究的参考书目，并联系了该领域的26名专家，以寻找未发表的工作。找到了32篇相关文章。包括横断面研究(n=20)和队列研究(n=11)，以及一项试验的对照组。在25项和15项分析中，分别根据SEP和种族/民族检查了CRP水平。在20项未调整或调整人口统计学变量的研究中，19项发现CRP水平和SEP之间存在负相关。在15项类似的研究中，14项发现了种族/民族之间的差异，即白人的C反应蛋白水平最低，而黑人、西班牙裔和南亚人的C反应蛋白水平最高。大多数研究还包括调整SEP或种族/民族与CRP之间因果关系链中的潜在中介变量。这些研究中的大多数都显示出减弱的但仍然显著的相关性。越来越多的贫困和非白人种族与成年人中C反应蛋白水平升高有关。文献中的大多数分析低估了种族/民族和社会经济因素的真实影响，因为对中介因素进行了调整。
Socioeconomic and racial/ethnic factors strongly influence cardiovascular disease outcomes and risk factors. C-reactive protein (CRP), a non-specific marker of inflammation, is associated with cardiovascular risk, and knowledge about its distribution in the population may help direct preventive efforts. A systematic review was undertaken to critically assess CRP levels according to socioeconomic and racial/ethnic factors. Medline was searched through December 2006 for population-based studies examining CRP levels among adults with respect to indicators of socioeconomic position (SEP) and/or race/ethnicity. Bibliographies from located studies were scanned and 26 experts in the field were contacted for unpublished work. Thirty-two relevant articles were located. Cross-sectional (n = 20) and cohort studies (n = 11) were included, as was the control group of one trial. CRP levels were examined with respect to SEP and race/ethnicity in 25 and 15 analyses, respectively. Of 20 studies that were unadjusted or adjusted for demographic variables, 19 found inverse associations between CRP levels and SEP. Of 15 similar studies, 14 found differences between racial/ethnic groups such that whites had the lowest while blacks, Hispanics and South Asians had the highest CRP levels. Most studies also included adjustment for potential mediating variables in the causal chain between SEP or race/ethnicity and CRP. Most of these studies showed attenuated but still significant associations. Increasing poverty and non-white race was associated with elevated CRP levels among adults. Most analyses in the literature are underestimating the true effects of racial/ethnic and socioeconomic factors due to adjustment for mediating factors.
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影响因子：
37.8
作者：
Blake, GJ;Rifai, N;Ridker, PM
通讯作者：
Ridker, PM
影响因子：
6.3
作者：
Jousilahti, P;Salomaa, V;Palosuo, T
通讯作者：
Palosuo, T
影响因子：
7.7
作者：
Dalstra, JAA;Kunst, AE;Mackenbach, JP
通讯作者：
Mackenbach, JP
影响因子：
168.9
作者：
Anand, SS;Yusuf, S;McQueen, M
通讯作者：
McQueen, M
影响因子：
8.3
作者：
Abramson, JL;Weintraub, WS;Vaccarino, V
通讯作者：
Vaccarino, V