NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.
NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.
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DOI：
10.1007/82_2010_107
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发表时间：
2011
影响因子：
--
通讯作者：
Silverman, Neal
中科院分区：
文献类型：
--
作者：
Ganesan, Sandhya;Aggarwal, Kamna;Paquette, Nicholas;Silverman, Neal
核因子-κB（NF-κB）/Rel转录因子形成先天免疫防御的组成部分并且在整个动物界中是保守的。研究这些因子的功能、激活和调节机制对于理解宿主对微生物感染的反应至关重要。果蝇已被证明是研究这些进化上保守的NF-κB介导的免疫应答的有价值的模型系统。果蝇通过体液免疫和细胞免疫反应对抗病原体。这些体液应答被很好地表征，并且以抗微生物肽组的稳健生产为标志。两个NF-κB信号通路，Toll和IMD通路，负责这些抗菌肽的诱导。这些途径中的信号转导与哺乳动物TLR途径中的信号转导惊人地相似。在本章中，我们详细讨论了微生物识别，信号转导和NF-κB调节的分子机制，在Toll和IMD途径。相似性和差异相对于他们的哺乳动物同行进行了讨论，并在我们的理解，这些NF-κB信号通路的复杂的监管网络的最新进展也突出显示。
Nuclear Factor-κB (NF-κB)/Rel transcription factors form an integral part of innate immune defenses and are conserved throughout the animal kingdom. Studying the function, mechanism of activation and regulation of these factors is crucial for understanding host responses to microbial infections. The fruit fly Drosophila melanogaster has proved to be a valuable model system to study these evolutionarily conserved NF-κB mediated immune responses. Drosophila combats pathogens through humoral and cellular immune responses. These humoral responses are well characterized and are marked by the robust production of a battery of anti-microbial peptides. Two NF-κB signaling pathways, the Toll and the IMD pathways, are responsible for the induction of these antimicrobial peptides. Signal transduction in these pathways is strikingly similar to that in mammalian TLR pathways. In this chapter, we discuss in detail the molecular mechanisms of microbial recognition, signal transduction and NF-κB regulation, in both the Toll and the IMD pathways. Similarities and differences relative to their mammalian counterparts are discussed, and recent advances in our understanding of the intricate regulatory networks in these NF-κB signaling pathways are also highlighted.
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影响因子：
3.7
作者：
Costa A;Jan E;Sarnow P;Schneider D
通讯作者：
Schneider D
影响因子：
9.8
作者：
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通讯作者：
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影响因子：
6.7
作者：
Bischoff V;Vignal C;Duvic B;Boneca IG;Hoffmann JA;Royet J
通讯作者：
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DOI：
10.1073/pnas.0903134106
发表时间：
2009-07-21
影响因子：
11.1
作者：
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通讯作者：
Gao, Fen-Biao
影响因子：
20.3
作者：
Cho, JH;Fraser, IP;Ezekowitz, RAB
通讯作者：
Ezekowitz, RAB