N-Acetyl-Aspartate in the dorsolateral prefrontal cortex in men with schizophrenia and auditory verbal hallucinations: A 1.5 T Magnetic Resonance Spectroscopy Study.
N-Acetyl-Aspartate in the dorsolateral prefrontal cortex in men with schizophrenia and auditory verbal hallucinations: A 1.5 T Magnetic Resonance Spectroscopy Study.
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DOI：
10.1038/s41598-018-22597-y
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发表时间：
2018-03-07
影响因子：
4.6
通讯作者：
Brunelin J
中科院分区：
文献类型：
--
作者：
Psomiades M;Mondino M;Fonteneau C;Bation R;Haesebaert F;Suaud-Chagny MF;Brunelin J
精神分裂症患者的听觉言语幻觉（AVH）与包括额叶和颞叶区域在内的大型大脑网络的异常有关。虽然额叶言语产生和颞叶言语感知区域的异常已被广泛研究，但与精神分裂症病理生理学密切相关的背外侧前额叶皮层（DLPFC）的改变很少与AVH相关。本研究采用1.5T质子磁共振波谱技术，探讨了精神分裂症患者左右侧DLPFCs N-乙酰天门冬氨酸（NAA）水平与AVH严重程度的关系。27例男性精神分裂症患者入组本研究，15例出现每日治疗抵抗性AVH（AVH+），12例报告无AVH（无AVH）。AVH+患者右侧DLPFC的NAA水平高于无AVH患者（p = 0.033）。在AVH+患者中，右侧DLPFC的NAA水平高于左侧（p = 0.024）。在非AVH患者中，观察到右侧和左侧DLPFC之间无差异。右侧DLPFC中NAA水平与AVH严重程度呈正相关（r = 0.404，p = 0.037）。尽管受到磁场强度的限制，这些结果表明，AVH可能与精神分裂症患者右侧DLPFC中NAA水平升高有关。
Auditory verbal hallucinations (AVH) in patients with schizophrenia are linked to abnormalities within a large cerebral network including frontal and temporal regions. Whilst abnormalities of frontal speech production and temporal speech perception regions have been extensively studied, alterations of the dorsolateral prefrontal cortex (DLPFC), a region critically involved in the pathophysiology of schizophrenia, have rarely been studied in relation to AVH. Using 1.5 T proton magnetic resonance spectroscopy, this study examined the relationship between right and left DLPFCs N-AcetylAspartate (NAA) levels and the severity of AVH in patients with schizophrenia. Twenty-seven male patients with schizophrenia were enrolled in this study, 15 presented daily treatment-resistant AVH (AVH+) and 12 reported no AVH (no-AVH). AVH+ patients displayed higher NAA levels in the right DLPFC than no-AVH patients (p = 0.033). In AVH+ patients, NAA levels were higher in the right DLPFC than in the left (p = 0.024). No difference between the right and left DLPFC was observed in no-AVH patients. There was a positive correlation between NAA levels in the right DLPFC and the severity of AVH (r = 0.404, p = 0.037). Despite limited by magnetic field strength, these results suggest that AVH may be associated with increased NAA levels in the right DLPFC in schizophrenia.
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影响因子：
3.1
作者：
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通讯作者：
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作者：
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