Aberrant connectivity of areas for decoding degraded speech in patients with auditory verbal hallucinations.
Aberrant connectivity of areas for decoding degraded speech in patients with auditory verbal hallucinations.
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DOI：
10.1007/s00429-013-0519-5
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发表时间：
2014-03
影响因子：
3.1
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Clos M;Diederen KM;Meijering AL;Sommer IE;Eickhoff SB
听觉言语幻觉（AVH）是精神病经历的一个标志。各种机制，包括内部言语的错误归因和自下而上和自上而下的因素之间的不平衡，在听觉感知可能是由于额叶和颞顶区之间的异常连接已被认为是AVH的基础。然而，实验证据表明，网络连接的干扰，维持词汇-言语加工是稀疏的。我们比较了49名频繁AVH的精神病患者和49名匹配的对照组的功能性静息状态连接。该分析是从左颞中回（MTG），丘脑，角回（AG）和额下回（IFG）播种，因为这些区域涉及从贫困的语音类声音中提取意义。所有种子均发现异常连接。在左侧MTG与其右侧同源体之间、左侧AG与周围顶下皮层（IPC）和左侧颞下回之间、左侧丘脑与右侧小脑之间以及左侧IFG与左侧IPC之间以及背外侧和腹外侧前额叶皮层（DLPFC/VLPFC）之间观察到连接性降低。观察到左侧IFG与辅助运动区（SMA）和左侧丘脑之间以及左侧丘脑与左侧梭状回/海马之间的连接增加。发生AVH的倾向可能是由于言语产生系统（IFG，VEGF-SMA和SMA）与自我监控系统（DLPFC，VLPFC，IPC）之间的解耦导致内部言语的错误归因。此外，参与语音处理的节点（AG，MTG）和参与听觉处理的其他区域之间的连接性降低可能反映了AVH中异常的自上而下的影响。
Auditory verbal hallucinations (AVH) are a hallmark of psychotic experience. Various mechanisms including misattribution of inner speech and imbalance between bottom-up and top-down factors in auditory perception potentially due to aberrant connectivity between frontal and temporo-parietal areas have been suggested to underlie AVH. Experimental evidence for disturbed connectivity of networks sustaining auditory-verbal processing is, however, sparse. We compared functional resting-state connectivity in 49 psychotic patients with frequent AVH and 49 matched controls. The analysis was seeded from the left middle temporal gyrus (MTG), thalamus, angular gyrus (AG) and inferior frontal gyrus (IFG) as these regions are implicated in extracting meaning from impoverished speech-like sounds. Aberrant connectivity was found for all seeds. Decreased connectivity was observed between the left MTG and its right homotope, between the left AG and the surrounding inferior parietal cortex (IPC) and the left inferior temporal gyrus, between the left thalamus and the right cerebellum, as well as between the left IFG and left IPC, and dorsolateral and ventrolateral prefrontal cortex (DLPFC/VLPFC). Increased connectivity was observed between the left IFG and the supplementary motor area (SMA) and the left insula and between the left thalamus and the left fusiform gyrus/hippocampus. The predisposition to experience AVH might result from decoupling between the speech production system (IFG, insula and SMA) and the self-monitoring system (DLPFC, VLPFC, IPC) leading to misattribution of inner speech. Furthermore, decreased connectivity between nodes involved in speech processing (AG, MTG) and other regions implicated in auditory processing might reflect aberrant top-down influences in AVH.
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影响因子：
6.6
作者：
Allen, Paul;Modinos, Gemma;Hoffman, Ralph
通讯作者：
Hoffman, Ralph
影响因子：
2.5
作者：
CIPOLLONI, PB;PANDYA, DN
通讯作者：
PANDYA, DN
影响因子：
17.7
作者：
Diederen, Kelly M. J.;Neggers, Sebastiaan F. W.;Sommer, Iris E. C.
通讯作者：
Sommer, Iris E. C.
影响因子：
14.5
作者：
BOTTINI, G;CORCORAN, R;FRITH, CD
通讯作者：
FRITH, CD
影响因子：
2.5
作者：
Choi, HJ;Zilles, K;Amunts, K
通讯作者：
Amunts, K