Bats experience age-related hearing loss (presbycusis).
Bats experience age-related hearing loss (presbycusis).
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蝙蝠会经历与年龄相关的听力损失(老年性耳聋)。
DOI：
10.26508/lsa.202201847
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发表时间：
2023-06
影响因子：
4.4
通讯作者：
中科院分区：
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蝙蝠表现出与年龄相关的听力损失。蝙蝠暴露在巨大的同种噪音中，但频率依赖性听力损失与噪音无关。听力损失是衰老的一个标志，最初通常影响较高的频率。在蝙蝠的回声定位中，辨别高频的能力是必不可少的。然而，我们对蝙蝠与年龄相关的听力损失一无所知，人们通常认为它们对听力损失免疫。我们测试了47只野生埃及果蝠的听力，记录了它们的听觉脑干反应和耳蜗微音，并评估了其中4只蝙蝠的耳蜗组织学。我们使用蝙蝠的DNA甲基化谱来评估它们的年龄，发现蝙蝠表现出与年龄相关的听力损失，在更高的频率上表现出更明显的退化。恶化的速度为每年约1 dB，与人类观察到的听力损失相当。对果蝠栖息地的噪音进行评估后发现，这些蝙蝠暴露在持续不断的巨大噪音中——大部分是群居的叫声——这支持了蝙蝠可能部分抵抗大声噪音的假设。因此，与之前的假设相反，我们的结果表明蝙蝠构成了研究与年龄相关的听力损失的模型动物。
Bats exhibited age-related hearing loss. Bats are exposed to immense conspecific noise, but the frequency-dependent hearing loss was not correlated to the noise. Hearing loss is a hallmark of aging, typically initially affecting the higher frequencies. In echolocating bats, the ability to discern high frequencies is essential. However, nothing is known about age-related hearing loss in bats, and they are often assumed to be immune to it. We tested the hearing of 47 wild Egyptian fruit bats by recording their auditory brainstem response and cochlear microphonics, and we also assessed the cochlear histology in four of these bats. We used the bats’ DNA methylation profile to evaluate their age and found that bats exhibit age-related hearing loss, with more prominent deterioration at the higher frequencies. The rate of the deterioration was ∼1 dB per year, comparable to the hearing loss observed in humans. Assessing the noise in the fruit bat roost revealed that these bats are exposed to continuous immense noise—mostly of social vocalizations—supporting the assumption that bats might be partially resistant to loud noise. Thus, in contrast to previous assumptions, our results suggest that bats constitute a model animal for the study of age-related hearing loss.
影响因子：
3.7
作者：
Mao B;Moss CF;Wilkinson GS
通讯作者：
Wilkinson GS
DOI：
10.1007/s00359-022-01559-w
发表时间：
2022-07
期刊：
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
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