Activation lateralization in human core, belt, and parabelt auditory fields with unilateral deafness compared to normal hearing.
Activation lateralization in human core, belt, and parabelt auditory fields with unilateral deafness compared to normal hearing.
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DOI：
10.1016/j.brainres.2012.02.066
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发表时间：
2012-05-15
期刊：
影响因子：
2.9
通讯作者：
Uchanski RM
中科院分区：
文献类型：
--
作者：
Burton H;Firszt JB;Holden T;Agato A;Uchanski RM
我们研究了正常听力（NH）和单侧听力损失（UHL）的成年人的核心、带和旁带听觉皮层的激活强度，采用中断的单事件设计和随机声谱声的单声刺激。NH患者有一只耳朵被阻塞，并在与UHL中完整耳朵相匹配的一侧接受刺激。目的是确定耳聋一侧是否影响侧化和不同听觉皮质场（ACFs）中诱发的血氧水平依赖性反应的大小。无论刺激的耳朵，NH在几个ACFs中表现出更大的对侧反应。在UHL的右耳刺激下，与NH相比，核心和带ACFs的同侧反应更大，表明右半球神经可塑性。在UHL的左耳刺激下，只有后核ACFs表现出更大的同侧反应，这表明左半球的大多数ACFs对来自右耳失传入的交叉输入减少具有更大的弹性。与NH相比，无论RE/LE刺激和侧化输入，UHL中位于核心和带状听觉皮层后外侧的旁带区域的激活程度都有所降低。因此，与NH相比，UHL的效果因ACF和耳聋而异。
We studied activation magnitudes in core, belt, and parabelt auditory cortex in adults with normal hearing (NH) and unilateral hearing loss (UHL) using an interrupted, single-event design and monaural stimulation with random spectrographic sounds. NH patients had one ear blocked and received stimulation on the side matching the intact ear in UHL. The objective was to determine whether the side of deafness affected lateralization and magnitude of evoked blood oxygen level-dependent responses across different auditory cortical fields (ACFs). Regardless of ear of stimulation, NH showed larger contralateral responses in several ACFs. With right ear stimulation in UHL, ipsilateral responses were larger compared to NH in core and belt ACFs, indicating neuroplasticity in the right hemisphere. With left ear stimulation in UHL, only posterior core ACFs showed larger ipsilateral responses, suggesting that most ACFs in the left hemisphere had greater resilience against reduced crossed inputs from a deafferented right ear. Parabelt regions located posterolateral to core and belt auditory cortex showed reduced activation in UHL compared to NH irrespective of RE/LE stimulation and lateralization of inputs. Thus, the effect in UHL compared to NH differed by ACF and ear of deafness.
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影响因子：
5.7
作者：
Humphries, Colin;Liebenthal, Einat;Binder, Jeffrey R.
通讯作者：
Binder, Jeffrey R.
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
2.4
作者：
Hanss, Julien;Veuillet, Evelyne;Thai-Van, Hung
通讯作者：
Thai-Van, Hung
影响因子：
2.5
作者：
GALABURDA, A;SANIDES, F
通讯作者：
SANIDES, F
影响因子：
3.3
作者：
FORMAN, SD;COHEN, JD;NOLL, DC
通讯作者：
NOLL, DC