Altered regional and circuit resting-state activity associated with unilateral hearing loss.
Altered regional and circuit resting-state activity associated with unilateral hearing loss.
复制标题
与单侧听力损失相关的区域和电路静息状态活动的改变
DOI：
10.1371/journal.pone.0096126
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Liu P
中科院分区：
文献类型：
--
作者：
Wang X;Fan Y;Zhao F;Wang Z;Ge J;Zhang K;Gao Z;Gao JH;Yang Y;Fan J;Zou Q;Liu P
听觉损伤后感觉输入的剥夺导致大脑的功能重组，包括感觉皮层的跨模态可塑性和认知过程的变化。然而，目前尚不清楚是否部分剥夺单侧听觉丧失（UHL）会同样影响神经回路的认知过程中除了感觉皮层的功能组织。在这里，我们使用静息态功能磁共振成像调查的内在活动，在34名参与者与UHL的听神经瘤与22名匹配的正常对照组相比。在感觉区域，我们发现减少区域均匀性（ReHo）在UHL的双边距状皮质。然而，在认知控制网络（CCN）和多模态感觉整合的关键节点右侧前岛叶皮层（rAI）以及默认模式网络（DMN）的关键节点左侧海马旁皮层（lPHC）中，ReHo增加。此外，基于种子的静息态功能连接分析表明，增强的关系之间的rAI和DMN的几个关键区域。同时，lPHC与CCN中的组分呈较强的负相关，与DMN中的组分呈较强的正相关。DMN内部以及DMN与CCN之间的功能连接的这种重组通过图论分析得到证实。这些结果表明，单侧感觉输入损伤不仅改变了感觉区的活动，而且重塑了认知控制网络的区域和回路功能组织。
The deprivation of sensory input after hearing damage results in functional reorganization of the brain including cross-modal plasticity in the sensory cortex and changes in cognitive processing. However, it remains unclear whether partial deprivation from unilateral auditory loss (UHL) would similarly affect the neural circuitry of cognitive processes in addition to the functional organization of sensory cortex. Here, we used resting-state functional magnetic resonance imaging to investigate intrinsic activity in 34 participants with UHL from acoustic neuroma in comparison with 22 matched normal controls. In sensory regions, we found decreased regional homogeneity (ReHo) in the bilateral calcarine cortices in UHL. However, there was an increase of ReHo in the right anterior insular cortex (rAI), the key node of cognitive control network (CCN) and multimodal sensory integration, as well as in the left parahippocampal cortex (lPHC), a key node in the default mode network (DMN). Moreover, seed-based resting–state functional connectivity analysis showed an enhanced relationship between rAI and several key regions of the DMN. Meanwhile, lPHC showed more negative relationship with components in the CCN and greater positive relationship in the DMN. Such reorganizations of functional connectivity within the DMN and between the DMN and CCN were confirmed by a graph theory analysis. These results suggest that unilateral sensory input damage not only alters the activity of the sensory areas but also reshapes the regional and circuit functional organization of the cognitive control network.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Cauda F;Costa T;Torta DM;Sacco K;D'Agata F;Duca S;Geminiani G;Fox PT;Vercelli A
通讯作者：
Vercelli A
影响因子：
1.7
作者：
Auer, Edward T., Jr.;Bernstein, Lynne E.;Singh, Manbir
通讯作者：
Singh, Manbir
影响因子：
2.5
作者：
Downar, J;Crawley, AP;Davis, KD
通讯作者：
Davis, KD
影响因子：
9.2
作者：
Driver, J;Spence, C
通讯作者：
Spence, C