Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005.
Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005.
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DOI：
10.1136/ard.2007.076232
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发表时间：
2008-07
影响因子：
27.4
通讯作者：
Nuki G
中科院分区：
文献类型：
--
作者：
Annemans L;Spaepen E;Gaskin M;Bonnemaire M;Malier V;Gilbert T;Nuki G
调查和比较英国和德国实践中痛风的患病率、合并症和治疗。使用IMS疾病分析仪对痛风患者进行回顾性分析，通过英国全科诊所的250万例患者和德国的240万例全科医生或内科医生的记录进行识别。英国和德国的痛风患病率为1.4%。肥胖是英国最常见的合并症（27.7%），但在德国，最常见的合并症是糖尿病（25.9%）。合并症的患病率随着血清尿酸（sUA）水平的升高而升高。血尿酸水平与痛风发作频率呈正相关。在英国和德国，与sUA <360 μmol/l（<6 mg/dl）的患者相比，sUA 360-420 μmol/l（6-7 mg/dl）时痛风发作的优势比分别为1.33和1.37，sUA >530 μmol/l（>9 mg/dl）时分别为2.15和2.48（p<0.01）。2000- 2005年，英国和德国实践中痛风的患病率为1.4%，与英国1990- 1999年的数据一致。慢性合并症在痛风患者中很常见，包括与心血管疾病风险增加相关的疾病，如肥胖、糖尿病和高血压。这项研究的数据突出了定期监测sUA以定制痛风治疗的重要性，这些数据显示，sUA水平> 360 μmol/l（> 6 mg/dl）的患者痛风发作的风险增加。
To investigate and compare the prevalence, comorbidities and management of gout in practice in the UK and Germany. A retrospective analysis of patients with gout, identified through the records of 2.5 million patients in UK general practices and 2.4 million patients attending GPs or internists in Germany, using the IMS Disease Analyzer. The prevalence of gout was 1.4% in the UK and Germany. Obesity was the most common comorbidity in the UK (27.7%), but in Germany the most common comorbidity was diabetes (25.9%). The prevalence of comorbidities tended to increase with serum uric acid (sUA) levels. There was a positive correlation between sUA level and the frequency of gout flares. Compared with those in whom sUA was <360 μmol/l (<6 mg/dl), odds ratios for a gout flare were 1.33 and 1.37 at sUA 360–420 μmol/l (6–7 mg/dl), and 2.15 and 2.48 at sUA >530 μmol/l ( >9 mg/dl) in the UK and Germany, respectively (p<0.01). The prevalence of gout in practice in the UK and Germany in the years 2000–5 was 1.4%, consistent with previous UK data for 1990–9. Chronic comorbidities were common among patients with gout and included conditions associated with an increased risk for cardiovascular disease, such as obesity, diabetes and hypertension. The importance of regular monitoring of sUA in order to tailor gout treatment was highlighted by data from this study showing that patients with sUA levels ⩾360 μmol/l (⩾6 mg/dl) had an increased risk of gout flares.
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影响因子：
27.4
作者：
CURRIE, WJC
通讯作者：
CURRIE, WJC
DOI：
10.1002/art.20405
发表时间：
2004-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Shoji, A;Yamanaka, H;Kamatani, N
通讯作者：
Kamatani, N
影响因子：
5.9
作者：
HANDE, KR;NOONE, RM;STONE, WJ
通讯作者：
STONE, WJ
DOI：
10.1002/art.22466
发表时间：
2007-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Choi, Hyon K.;Ford, Earl S.;Curhan, Gary
通讯作者：
Curhan, Gary
DOI：
10.1002/art.10511
发表时间：
2002-08-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Perez-Ruiz, F;Calabozo, M;Ruibal, A
通讯作者：
Ruibal, A