Effects of Neurointermediate Pituitary Lobectomy and Desmopressin on Acute Experimental Autoimmune Encephalomyelitis in Lewis Rats
Effects of Neurointermediate Pituitary Lobectomy and Desmopressin on Acute Experimental Autoimmune Encephalomyelitis in Lewis Rats
复制标题
垂体神经中叶切除术和去氨加压素对Lewis大鼠急性实验性自身免疫性脑脊髓炎的影响
作者：
A. Quintanar;Alejandro Organista‐Esparza;R. Chavira;K. Kovacs;I. Bérczi
目的：精氨酸加压素（AVP）作为一种直接的免疫调节剂的作用尚未得到澄清，需要更多的工作来评估其参与免疫神经内分泌网络。本研究观察了垂体神经中间叶切除术（NIL）和AVP激动剂去氨加压素（DP）对雌性刘易斯大鼠急性实验性自身免疫性脑脊髓炎（EAE）的影响。下丘脑-垂体-肾上腺皮质（HPA）轴的活动也进行了评估。研究方法：实验分为5组：（1）假手术组（SHAM）、（2）假手术+ DP组、（3）NIL组、（4）NIL + DP组和（5）未处理的正常对照组。术后2周开始DP治疗，1周后进行诱导EAE的免疫接种。结果：SHAM大鼠出现了EAE和HPA轴激活的全面临床和组织学体征。假手术+ DP动物具有EAE的轻度临床体征、脊髓中的炎性浸润和激活的HPA轴。NIL动物发生了极轻微的EAE，少量脊髓炎症，HPA轴活性无变化。NIL + DP大鼠出现严重的EAE临床体征、广泛的脊髓炎性浸润和HPA轴的显著激活。结论：NIL降低了细胞免疫应答，而DP在NIL动物中恢复了免疫应答。AVP直接参与免疫能力的维持。
Objective: The role of arginine vasopressin (AVP) as a direct immune regulator has not yet been clarified, and more work is needed to assess its involvement in the immunoneuroendocrine network. In the present study, the effects of neurointermediate pituitary lobectomy (NIL) and desmopressin (DP), an agonist of AVP, on acute experimental autoimmune encephalomyelitis (EAE) in female Lewis rats were evaluated. The activity of the hypothalamic-pituitary-adrenocortical (HPA) axis was also assessed. Methods: Five groups of rats were used, as follows: (1) sham-operated (SHAM) rats, (2) SHAM + DP rats, (3) NIL rats, (4) NIL + DP rats and (5) untreated normal control rats. DP treatment started 2 weeks after surgery, and immunization to induce EAE was carried out 1 week later. Results: SHAM rats developed full-blown clinical and histological signs of EAE and activation of the HPA axis. SHAM + DP animals had mild clinical signs of EAE, inflammatory infiltrations in the spinal cord and an activated HPA axis. NIL animals developed minimal EAE, scanty spinal cord inflammation and no changes in HPA axis activity. NIL + DP rats developed severe clinical signs of EAE, extensive spinal cord inflammatory infiltrations and marked activation of the HPA axis. Conclusions: NIL decreased the cell-mediated immune response, while DP in NIL animals restored the immune response. AVP is directly involved in the maintenance of immune competence.
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影响因子：
--
作者：
H. Garza;D. Carr
通讯作者：
H. Garza;D. Carr
神经内分泌肽激素调节免疫。
DOI：
10.1159/000058657
发表时间：
1997
期刊：
Chemical immunology.
影响因子：
--
作者：
Torres,BA;Johnson,HM
通讯作者：
Johnson,HM
精氨酸加压素对自体混合淋巴细胞反应的影响。
DOI：
10.1016/0192-0561(92)90109-x
发表时间：
1992
期刊：
International journal of immunopharmacology
影响因子：
--
作者：
Bell,J;Adler,MW;Greenstein,JI
通讯作者：
Greenstein,JI
精氨酸加压素 (AVP) 替代 IFN-γ 生产中辅助细胞的需求。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Torres,BA;Johnson,HM
通讯作者：
Johnson,HM