A pilot study of cortical glutathione in youth with depression.
A pilot study of cortical glutathione in youth with depression.
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DOI：
10.1016/j.pscychresns.2017.10.001
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发表时间：
2017-12-30
期刊：
影响因子：
--
通讯作者：
Gabbay V
中科院分区：
文献类型：
--
作者：
Freed RD;Hollenhorst CN;Weiduschat N;Mao X;Kang G;Shungu DC;Gabbay V
本研究采用质子磁共振波谱法（1H MRS）测定青少年重度抑郁症（MDD）患者体内脑谷胱甘肽（GSH）水平，探讨GSH与病情严重程度和慢性程度的关系。其次，研究了谷胱甘肽与青少年重度抑郁症的关键症状快感缺乏之间的关系。测定了19例无精神药物治疗的MDD青少年（12-21岁）枕叶皮质谷胱甘肽水平，并与8名健康对照青少年进行了比较。GSH水平与快感缺乏症严重程度之间的相关性在所有参与者样本和重度抑郁症组中都得到了检验。在重度抑郁症组中，评估谷胱甘肽水平与疾病严重程度和慢性程度之间的相关性。与对照组相比，患有重度抑郁症的青少年枕部谷胱甘肽水平较低，但与快感缺乏症（无论是在重度抑郁症组还是整个样本中）、重度抑郁症或发病无关。总胆碱、肌酸和n -乙酰天冬氨酸水平也没有组间差异——所有的神经代谢物都是同时用1H mrs检测到的，尽管是初步的，但研究结果增加了新的数据来支持氧化应激在MDD中的作用，并表明较低的谷胱甘肽可能是疾病早期MDD的潜在标志。
This study used proton magnetic resonance spectroscopy (1H MRS) to measure in vivo brain glutathione (GSH) in adolescents with major depressive disorder (MDD), and explored the relationship between GSH and illness severity and chronicity. Secondarily, associations between GSH and anhedonia, a key symptom of MDD in adolescents, were investigated. Occipital cortex GSH levels were obtained in 19 psychotropic medication-free adolescents with MDD (ages 12–21) and compared to those in eight healthy control adolescents. Correlations between GSH levels and anhedonia severity were examined both in the full participant sample and within the MDD group. Within the MDD group, correlations between GSH levels and illness severity and chronicity were assessed. Occipital GSH levels were lower in adolescents with MDD compared to controls, but did not correlate with anhedonia (either within the MDD group or the full sample), MDD severity, or onset. There were also no group differences in levels of total choline, creatine, and N-acetylaspartate – all neurometabolites that were simultaneously detected with 1H MRS. Although preliminary, findings add new data to support the role of oxidative stress in MDD and suggest that lower GSH may be a potential marker of MDD early on in the course of illness.
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影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
7.6
作者：
Asarnow, JR;Jaycox, LH;Wells, KB
通讯作者：
Wells, KB
影响因子：
3.3
作者：
Gabbay, Vilma;Ely, Benjamin A.;Liebes, Leonard
通讯作者：
Liebes, Leonard
影响因子：
3.4
作者：
Godlewska, Beata R.;Near, Jamie;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
5.3
作者：
Jimenez-Fernandez, Sara;Gurpegui, Manuel;Correll, Christoph U.
通讯作者：
Correll, Christoph U.