Neurochemistry of major depression: a study using magnetic resonance spectroscopy.
Neurochemistry of major depression: a study using magnetic resonance spectroscopy.
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DOI：
10.1007/s00213-014-3687-y
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发表时间：
2015-02
影响因子：
3.4
通讯作者：
Cowen, Philip J.
中科院分区：
文献类型：
--
作者：
Godlewska, Beata R.;Near, Jamie;Cowen, Philip J.
磁共振波谱（MRS）是一种可接受的非侵入性研究抑郁症脑神经化学的手段。以往对抑郁症患者的研究主要集中在氨基酸神经递质γ-氨基丁酸（GABA）和谷氨酸的测定上。本研究的目的是使用MRS结合超短回波时间“SPECIAL”技术来测量未服药的重度抑郁症患者的GABA、谷氨酸和谷胱甘肽（GSH）皮质水平。我们还检查了选择性5 -羟色胺再摄取抑制剂艾司西酞普兰6周治疗的效果。我们使用质子mrs研究了DSM-IV重度抑郁症患者和年龄匹配的健康对照者，测量了放置在枕叶皮层的体素中GABA、谷氨酸和谷胱甘肽相对于肌酸的含量。抑郁参与者和对照组之间GABA和谷氨酸水平没有差异；然而，抑郁症患者的谷胱甘肽水平较低。6周的艾司西酞普兰治疗在一些患者中产生了显著的临床反应，但没有改变GABA、谷氨酸或谷胱甘肽的浓度。不同抑郁患者研究中GABA和谷氨酸测量差异的来源有待进一步研究。我们的结果表明，选择性5 -羟色胺再摄取抑制剂（SSRIs）的联合治疗不太可能是一个重要的混杂因素。如果谷胱甘肽水平降低可以被证实，它们可能代表一些抑郁症患者存在氧化应激。
Magnetic resonance spectroscopy (MRS) is an acceptable non-invasive means of studying brain neurochemistry in depression. Previous studies in depressed patients have focused on measurement of the amino acid neurotransmitters, γ-aminobutyric acid (GABA) and glutamate. The aim of this study is to use MRS in conjunction with the ultrashort echo time ‘SPECIAL’ technique to measure cortical levels of GABA, glutamate and glutathione (GSH) levels in unmedicated patients with major depression. We also examined the effect of 6-week treatment with the selective serotonin re-uptake inhibitor, escitalopram. We studied patients with DSM-IV major depression and healthy age-matched controls using proton MRS. GABA, glutamate and GSH were measured relative to creatine in a voxel placed in occipital cortex. There was no difference in GABA or glutamate levels between depressed participants and controls; however, depressed patients had lower GSH levels. Six-week escitalopram treatment, which resulted in significant clinical responses in some patients, did not alter concentrations of GABA, glutamate or GSH. The sources of variability of GABA and glutamate measures in different studies of depressed patients require further study. Our results suggest that concomitant treatment with selective serotonin re-uptake inhibitors (SSRIs) is unlikely to be an important confounding factor. If lowered GSH levels can be confirmed, they may represent the presence of oxidative stress in some depressed patients.
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影响因子：
168.9
作者：
Kupfer, David J.;Frank, Ellen;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
影响因子：
3.4
作者：
Godlewska, Beata R.;Yip, Sarah W.;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
2.9
作者：
Near, Jamie;Andersson, Jesper;Jezzard, Peter
通讯作者：
Jezzard, Peter
影响因子：
--
作者：
Sanacora, G;Gueorguieva, R;Mason, GF
通讯作者：
Mason, GF
影响因子：
2.9
作者：
Murrough, James W.;Mao, Xiangling;Shungu, Dikoma C.
通讯作者：
Shungu, Dikoma C.