Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype.
Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype.
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血清磷脂、脂肪酸与乳腺癌病理亚型的关系
DOI：
10.3390/nu12103132
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发表时间：
2020-10-14
期刊：
影响因子：
5.9
通讯作者：
Pollán M
中科院分区：
文献类型：
--
作者：
Lope V;Guerrero-Zotano Á;Casas A;Baena-Cañada JM;Bermejo B;Pérez-Gómez B;Criado-Navarro I;Antolín S;Sánchez-Rovira P;Ramos-Vázquez M;Antón A;Castelló A;García-Saénz JÁ;Muñoz M;de Juan A;Andrés R;Llombart-Cussac A;Hernando B;Franquesa RM;Caballero R;Priego-Capote F;Martín M;Pollán M
本研究评估血清磷脂脂肪酸 (PL-FA) 及其内源代谢标志物是否与乳腺癌 (BC) 亚型相关。 EpiGEICAM 是一项西班牙多中心匹配病例对照研究。 1017 名 BC 病例和健康女性对完成了生活方式和食物频率调查问卷。通过气相色谱-质谱法测量血清 PL-FA 百分比。使用条件和多项 Logistic 回归模型来量化 PL-FA 三分位数与 BC 风险的总体风险和病理亚型（管腔、HER2+ 和三阴性）之间的关联。还根据体重指数和绝经状态进行了分层分析。测量了 795 对 (78%) 的血清 PL-FA。血清硬脂酸（优势比 (OR)T3vsT1 = 0.44；95% 置信区间 (CI) = 0.30–0.66）、亚油酸（ORT3vsT1 = 0.66；95% CI = 0.49–0.90）和花生四烯酸与二高-γ-亚麻酸比率（OR T3vsT1 = 0.64；95% CI = 0.48–0.84）显示 BC 风险较低。高浓度棕榈油酸（ORT3vsT1 = 1.65；95% CI = 1.20–2.26）、跨反刍动物棕榈油酸（ORT3vsT1 = 1.51；95% CI = 1.12–2.02）、跨工业反油酸（ORT3vsT1 = 1.52；95% CI = 1.14–2.03），高油酸与硬脂酸比例（ORT3vsT1 = 2.04；95% CI = 1.45–2.87）显示较高风险。这些关联在所有 BC 病理亚型中都是相似的。我们的结果强调了单独分析脂肪酸以及去饱和酶活性指数的重要性。
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
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影响因子：
5.4
作者：
GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
5
作者：
Chajes, Veronique;Thiebaut, Anne C. M.;Clavel-Chapelon, Francoise
通讯作者：
Clavel-Chapelon, Francoise
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.7
作者：
Chajes, Veronique;Biessy, Carine;Slimani, Nadia
通讯作者：
Slimani, Nadia
DOI：
10.1016/j.jand.2014.11.021
发表时间：
2015-02-01
影响因子：
4.8
作者：
Cunningham, Eleese
通讯作者：
Cunningham, Eleese