Exposure to toxic elements via breast milk.
Exposure to toxic elements via breast milk.
复制标题
通过母乳接触有毒元素。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
J. Sundberg
中科院分区：
文献类型：
--
作者：
A. Oskarsson;I. P. Hallén;J. Sundberg
母乳是新生儿的理想营养，但不幸的是，也是一些有毒物质的排泄途径。很少有人注意到母乳是接触有毒元素的来源。在大鼠和小鼠的实验模型中研究了无机汞、甲基汞和铅在母乳中的剂量依赖性排泄以及新生儿中的摄取。研究发现，与甲基汞相比，接触无机汞的母鼠体内汞从血浆向乳汁的转移率更高。相比之下，从牛奶中吸收的汞是较高的母鼠接触甲基汞比无机汞的幼崽。出生前后接触甲基汞会导致小鼠后代胸腺细胞亚群数量增加和比例改变，淋巴细胞活动增加，还会影响发育中的大鼠大脑中去甲肾上腺素和神经生长因子的水平。研究了瑞典哺乳期妇女血液和母乳中的汞与鱼类和汞合金中汞暴露的关系。发现的浓度水平较低;牛奶中的平均浓度为0.6纳克/克，血液中的平均浓度为2.3纳克/克。血液和牛奶中的汞含量之间存在统计学显著相关性，表明牛奶中的汞含量约为血液中汞含量的30%。汞合金中的无机汞暴露反映在血液和牛奶中的汞水平上。最近因食用鱼类而接触甲基汞的情况反映在血液中的汞含量上，但牛奶中的汞含量没有反映出来。（250字处删节）
Breast milk is the ideal nutrient for the newborn, but unfortunately also a route of excretion for some toxic substances. Very little attention has been paid to breast milk as a source of exposure to toxic elements. The dose-dependent excretion is breast milk and the uptake in the neonate of inorganic mercury, methylmercury and lead were studied in an experimental model for rats and mice. The transfer of mercury from plasma to milk was found to be higher in dams exposed to inorganic mercury than to methylmercury. In contrast, the uptake of mercury from milk was higher in the sucklings of dams exposed to methylmercury than to inorganic mercury. Pre- and postnatal exposure to methylmercury resulted in increased numbers and altered proportions of the thymocyte subpopulation and increased lymphocyte activities in the offspring of mice and also effects on the levels of noradrenaline and nerve growth factor in the developing brain of rats. Mercury in blood and breast milk in lactating women in Sweden was studied in relation to the exposure to mercury from, fish and amalgam. Low levels were found; the mean levels were 0.6 ng g-1 in milk and 2.3 ng g-1 in blood. There was a statistically significant correlation between mercury levels in blood and milk, showing that milk levels were approximately 30% of the levels in blood. Inorganic mercury exposure from amalgam was reflected in blood and milk mercury levels. Recent exposure to methylmercury from consumption of fish was reflected in mercury levels in the blood but not in milk.(ABSTRACT TRUNCATED AT 250 WORDS)
生命早期接触铅：健康后果。
DOI：
10.1007/978-1-4612-3416-6_3
发表时间：
1990
影响因子：
6
作者：
Hammond,PB;Dietrich,KN
通讯作者：
Dietrich,KN
哺乳期小鼠的骨铅动员以及铅向哺乳后代的转移。
影响因子：
3.8
作者：
Keller,CA;Doherty,RA
通讯作者：
Doherty,RA