Mushroom bodies are required for accurate visual navigation in ants
Mushroom bodies are required for accurate visual navigation in ants
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蚂蚁需要蘑菇体来进行准确的视觉导航
DOI：
10.1101/2020.05.13.094300
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Buehlmann C
中科院分区：
文献类型：
--
作者：
Buehlmann C
蚂蚁的视觉导航长期以来一直是实验研究的焦点[-]，但直到最近才提出了关于潜在神经回路的明确假设。间接证据表明，蘑菇体（MB），一个已知的嗅觉学习位点[-]，也可能是导航任务中视觉记忆的底物[-]。计算模型表明，MB神经结构可以支持这一功能，尽管没有直接证据表明蚂蚁需要MB进行视觉导航。在这里，我们表明，MB萼的病变损害蚂蚁的视觉导航到一个记住的食物位置，而离开他们的先天反应的视觉线索不受影响。蚂蚁天生会被一个大的视觉线索所吸引，但我们训练它们以这个视觉线索的特定角度定位食物来源。随后的双边或单边病变（通过盐酸普鲁卡因注射）的MB盏，导致蚂蚁恢复到他们的先天线索的吸引力，而控制（盐水）注射的蚂蚁仍然接近饲养。蚂蚁的路径平直度和行走速度不受病变的影响。无论是同侧还是对侧病变部位，都发生了朝向提示方向的逆转，表明这不仅仅是由于诱导的运动偏差。单眼阻塞并没有降低蚂蚁定位喂食器的能力，这表明病变不仅仅是中断了对花萼的视觉输入。先天和学习的视觉反应之间的分离证明了MB在导航记忆中的特定作用提供了直接证据。
Visual navigation in ants has long been a focus of experimental study [–], but only recently have explicit hypotheses about the underlying neural circuitry been proposed . Indirect evidence suggests the mushroom bodies (MB), a known site of olfactory learning [–], may also be the substrate for visual memory in navigation tasks [–]. Computational modelling shows that MB neural architecture could support this function [, ], though there is no direct evidence that ants require MBs for visual navigation. Here we show that lesions of MB calyces impair ants’ visual navigation to a remembered food location whilst leaving their innate responses to visual cues unaffected. Ants are innately attracted to a large visual cue but we trained them to locate a food source at a specific angle to this visual cue. Subsequent bilateral or unilateral lesioning (through procaine hydrochloride injection) of the MB calyces, caused ants to revert to their innate cue attraction whilst control (saline) injected ants still approached the feeder. The ants’ path straightness and walking speed were unaffected by lesions. Reversion towards the cue direction occurred irrespective of whether it was ipsi-or contralateral to the lesion site, showing this is not due simply to an induced motor bias. Monocular occlusion did not diminish ants’ ability to locate the feeder, suggesting the lesion is not merely interrupting visual input to the calyx. The demonstrated dissociation between innate and learnt visual responses provides direct evidence for a specific role of the MB in navigational memory.
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影响因子：
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DOI：
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DOI：
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