Disease-inspired tissue engineering: Investigation of cardiovascular pathologies.
Disease-inspired tissue engineering: Investigation of cardiovascular pathologies.
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DOI：
10.1021/acsbiomaterials.9b01067
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发表时间：
2020-05-11
影响因子：
5.8
通讯作者：
Masters KS
中科院分区：
文献类型：
--
作者：
Simon LR;Masters KS
Once focused exclusively on the creation of tissues to repair or replace diseased or damaged organs, the field of tissue engineering has undergone an important evolution in recent years. Namely, tissue engineering techniques are increasingly being applied to intentionally generate pathological conditions. Motivated in part by the wide gap between 2D cultures and animal models in the current disease modeling continuum, disease-inspired tissue-engineered platforms have numerous potential applications, and may serve to advance our understanding and clinical treatment of various diseases. This review will focus on recent progress toward generating tissue-engineered models of cardiovascular diseases, including cardiac hypertrophy, fibrosis, and ischemia reperfusion injury, atherosclerosis, and calcific aortic valve disease, with an emphasis on how these disease-inspired platforms can be used to decipher disease etiology. Each pathology is discussed in the context of generating both disease-specific cells as well as disease-specific extracellular environments, with an eye toward future opportunities to integrate different tools to yield more complex and physiologically relevant culture platforms. Ultimately, the development of effective disease treatments relies upon our ability to develop appropriate experimental models; as cardiovascular diseases are the leading cause of death worldwide, the insights yielded by improved in vitro disease modeling could have substantial ramifications for public health and clinical care.
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DOI：
10.1161/atvbaha.116.307301
发表时间：
2017-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Arnold AP;Cassis LA;Eghbali M;Reue K;Sandberg K
通讯作者：
Sandberg K
推进人类来源的生物材料用于组织工程
影响因子：
27.1
作者：
Chen FM;Liu X
通讯作者：
Liu X
影响因子：
4.6
作者：
Dohmen, PM;Lembcke, A;Konertz, WF
通讯作者：
Konertz, WF
性别特异性的eNOS活性和人类内皮细胞的功能。
影响因子：
4.6
作者：
Cattaneo MG;Vanetti C;Decimo I;Di Chio M;Martano G;Garrone G;Bifari F;Vicentini LM
通讯作者：
Vicentini LM
DOI：
10.1007/s12471-017-0959-2
发表时间：
2017-04
期刊：
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
影响因子：
--
作者：
Bergheanu SC;Bodde MC;Jukema JW
通讯作者：
Jukema JW