Energetics of Cardiac Blood Flow in Hypertrophic Cardiomyopathy through Individualized Computational Modeling.
Energetics of Cardiac Blood Flow in Hypertrophic Cardiomyopathy through Individualized Computational Modeling.
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DOI：
10.3390/jcdd10100411
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发表时间：
2023-09-27
影响因子：
2.4
通讯作者：
Rugonyi S
中科院分区：
文献类型：
--
作者：
Baenen O;Carreño-Martínez AC;Abraham TP;Rugonyi S
肥厚型心肌病（HCM）是一种先天性心脏病，其特征是心脏左心室（LV）壁增厚，可导致心功能障碍和心力衰竭。心室壁增厚影响心脏壁的运动和心脏内的血流。由于异常的心脏血流反过来可能导致心脏壁的有害重塑，异常的心室血流模式可能会加剧HCM的进展。血流模式如何受到肥大和患者间变异性的影响尚不清楚。为了解决这一知识差距，我们在这里提出的策略，以生成个性化的计算流体动力学（CFD）模型的心脏LV从患者的心脏磁共振（cMR）图像。我们从三种情况（一种正常，两种HCM）进行了CFD LV模型的模拟。计算流体动力学计算解决了血流速度，从流模式和能量的LV内的流动进行了量化。我们发现，与正常心脏相比，HCM心脏表现出异常的血流模式和从LV壁到血流的能量转移的时间不匹配，以及动能流模式的变化。虽然我们的结果是初步的，我们提出的方法有希望在临床实践中深入分析HCM患者的血流动力学。
Hypertrophic cardiomyopathy (HCM) is a congenital heart disease characterized by thickening of the heart’s left ventricle (LV) wall that can lead to cardiac dysfunction and heart failure. Ventricular wall thickening affects the motion of cardiac walls and blood flow within the heart. Because abnormal cardiac blood flow in turn could lead to detrimental remodeling of heart walls, aberrant ventricular flow patterns could exacerbate HCM progression. How blood flow patterns are affected by hypertrophy and inter-patient variability is not known. To address this gap in knowledge, we present here strategies to generate personalized computational fluid dynamics (CFD) models of the heart LV from patient cardiac magnetic resonance (cMR) images. We performed simulations of CFD LV models from three cases (one normal, two HCM). CFD computations solved for blood flow velocities, from which flow patterns and the energetics of flow within the LV were quantified. We found that, compared to a normal heart, HCM hearts exhibit anomalous flow patterns and a mismatch in the timing of energy transfer from the LV wall to blood flow, as well as changes in kinetic energy flow patterns. While our results are preliminary, our presented methodology holds promise for in-depth analysis of HCM patient hemodynamics in clinical practice.
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影响因子：
4
作者：
Fumagalli I;Vitullo P;Vergara C;Fedele M;Corno AF;Ippolito S;Scrofani R;Quarteroni A
通讯作者：
Quarteroni A
DOI：
10.1136/heartjnl-2015-308044
发表时间：
2016-01
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Morris PD;Narracott A;von Tengg-Kobligk H;Silva Soto DA;Hsiao S;Lungu A;Evans P;Bressloff NW;Lawford PV;Hose DR;Gunn JP
通讯作者：
Gunn JP
影响因子：
37.8
作者：
MARON, BJ;GARDIN, JM;BILD, DE
通讯作者：
BILD, DE
影响因子：
14
作者：
Afonso, Luis C.;Bernal, Juan;Abraham, Theodore P.
通讯作者：
Abraham, Theodore P.
心脏成像中的最新技术。
影响因子：
--
作者：
Counseller, Quinn;Aboelkassem, Yasser
通讯作者：
Aboelkassem, Yasser