Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension.
Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension.
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DOI：
10.3389/fendo.2021.631848
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发表时间：
2021
影响因子：
5.2
通讯作者：
Azizan EA
中科院分区：
文献类型：
--
作者：
Pauzi FA;Azizan EA
原发性醛固酮增多症（PA）是继发性高血压最常见的可治愈形式之一。它可能是由一个或两个肾上腺中的醛固酮过度产生引起的。PA最常见的亚型是由醛固酮生成腺瘤（阿帕）引起的单侧醛固酮过度生成或由双侧醛固酮增多症（BHA）引起的双侧醛固酮过度生成。利用醛固酮合成酶（CYP11 B2）的免疫组化（IHC）检测允许识别醛固酮产生细胞簇（APCC），其在人成人肾上腺皮质的被膜下部分具有CYP11 B2表达阳性的独特局灶性定位。CYP11B2的存在支持醛固酮的合成可以发生在这些细胞簇中，因此可能有助于醛固酮增多症。然而，APCCs的类固醇生成特性的意义，特别是在PA方面仍然不清楚。在此，我们回顾了现有的证据存在APCCs在正常肾上腺和肾上腺组织附近的APA，其醛固酮刺激体细胞基因突变，其积累在衰老过程中，提高APCCs可能发挥作用的PA和年龄相关性高血压的发展。
Primary aldosteronism (PA) is one of the most frequent curable forms of secondary hypertension. It can be caused by the overproduction of aldosterone in one or both adrenal glands. The most common subtypes of PA are unilateral aldosterone over-production due to aldosterone-producing adenomas (APA) or bilateral aldosterone over-production due to bilateral hyperaldosteronism (BHA). Utilizing the immunohistochemical (IHC) detection of aldosterone synthase (CYP11B2) has allowed the identification of aldosterone-producing cell clusters (APCCs) with unique focal localization positive for CYP11B2 expression in the subcapsular portion of the human adult adrenal cortex. The presence of CYP11B2 supports that synthesis of aldosterone can occur in these cell clusters and therefore might contribute to hyperaldosteronism. However, the significance of the steroidogenic properties of APCCs especially in regards to PA remains unclear. Herein, we review the available evidence on the presence of APCCs in normal adrenals and adrenal tissues adjacent to APAs, their aldosterone-stimulating somatic gene mutations, and their accumulation during the ageing process; raising the possibility that APCCs may play a role in the development of PA and age-related hypertension.
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影响因子：
2.5
作者：
Catterall WA
通讯作者：
Catterall WA
影响因子：
4.1
作者：
Hattangady, Namita G.;Olala, Lawrence O.;Bollag, Wendy B.;Rainey, William E.
通讯作者：
Rainey, William E.
DOI：
10.1055/a-1128-0421
发表时间：
2020-06
期刊：
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
影响因子：
--
作者：
Lim JS;Rainey WE
通讯作者：
Rainey WE
影响因子：
30.8
作者：
Azizan, Elena A. B.;Poulsen, Hanne;Brown, Morris J.
通讯作者：
Brown, Morris J.
影响因子：
5.8
作者：
Funder, John W.;Carey, Robert M.;Young, William F., Jr.
通讯作者：
Young, William F., Jr.