Gender-specific differences in birthweight and the odds of puberty: NHANES III, 1988-94.
Gender-specific differences in birthweight and the odds of puberty: NHANES III, 1988-94.
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DOI：
10.1111/j.1365-3016.2010.01097.x
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发表时间：
2010-05
影响因子：
2.8
通讯作者：
Forman MR
中科院分区：
文献类型：
--
作者：
Olivo-Marston S;Graubard BI;Visvanathan K;Forman MR
采用1988-1994年第三次国民健康与营养调查(NHANES III)研究了8-11岁女孩和8-12岁男孩的出生体重与青春期状况的优势比(OR)之间的关系。有出生体重和Tanner分期数据的女孩(n=956)和男孩(n=1199)包括在内。母亲报告的出生体重、怀孕期间吸烟和其他信息是在家庭访谈中提供的，而评估青春期状况的坦纳分期是体检的一部分。在对NHANES、年龄、种族、身高和体重指数(BMI)的复杂抽样设计进行调整后，计算了非同步青春期途径中Tanner阶段2+与1或2+与1的OR[95%可信区间(CI)]终点的多元Logistic回归模型。在女孩中，出生体重与Tanner阶段2+的OR无关；然而，出生体重低(2500 G)的男孩和出生时高于平均出生体重(3500-3999 g)的男孩更有可能是Tanner阶段2+，而不是1。儿童期BMI与女孩进入青春期的OR相关，但与男孩无关。在对非同步成熟的分析中，出生体重较高(>；4000 g)的女孩比正常出生体重的女孩更有可能有3+以上的乳房发育，OR=3.18[95%CI 1.39，8.25]。因此，出生体重与青春期的关联因性别和青春期途径而异。我们的发现需要在前瞻性纵向研究和研究中重复，以了解早期生命暴露与癌症风险之间关系的潜在机制。
The association between birthweight and the odds ratio (OR) of pubertal status in girls aged between 8 and 11 and in boys aged between 8 and 12 was examined using the 1988–94 Third National Health and Nutrition Examination Survey (NHANES III). Girls (n = 956), and boys (n = 1199), who had data on birthweight and Tanner staging were included. Maternal-reported birthweight, smoking in pregnancy and other information were provided in a home interview, while Tanner staging to assess pubertal status was part of a medical examination. Multiple logistic regression models were computed for the endpoints of the OR [95% confidence interval (CI)] of being Tanner Stage 2+ vs. 1 or being 2+ vs. 1 in an asynchronous pubertal pathway after adjustment for the complex sampling design of NHANES, age, race, height and body mass index (BMI). Birthweight was not associated with the OR of Tanner stage 2+ among girls; however, boys who were low birthweight (<2500 g) and boys born higher than average birthweight (3500–3999 g) were more likely to be Tanner stage 2+ than 1. Childhood BMI was associated with the OR of having entered puberty among girls, but not boys. In an analysis of asynchronous maturation, girls born at high birthweight (>4000 g) were more likely to have breast development 3+ than girls of normal birthweight, OR = 3.18 [95% CI 1.39, 8.25]. Thus, the birthweight–puberty association varies by gender and by pubertal pathway. Our findings need replication in prospective longitudinal studies, and research to understand the mechanisms underlying the relation of early life exposures to cancer risk.
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影响因子：
8
作者：
Anderson, SE;Dallal, GE;Must, A
通讯作者：
Must, A
影响因子：
8
作者：
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通讯作者：
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DOI：
10.1034/j.1600-0412.2000.079006485.x
发表时间：
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影响因子：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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