Subtyping Cryptosporidium ubiquitum,a zoonotic pathogen emerging in humans.
Subtyping Cryptosporidium ubiquitum,a zoonotic pathogen emerging in humans.
复制标题
DOI：
10.3201/eid2002.121797
复制
发表时间：
2014-02
影响因子：
11.8
通讯作者：
Feng Y
中科院分区：
文献类型：
--
作者：
Li N;Xiao L;Alderisio K;Elwin K;Cebelinski E;Chalmers R;Santin M;Fayer R;Kvac M;Ryan U;Sak B;Stanko M;Guo Y;Wang L;Zhang L;Cai J;Roellig D;Feng Y
隐孢子虫是一种新兴的人畜共患病原体。过去，无法确定人类和动物感染病例之间的关联。我们对该物种进行了基因组调查，开发了一种针对60 kDa糖蛋白（gp 60）基因的亚型分型工具，并确定了6个C亚型家族（XIIa-XIIf）。无处不在宿主适应在gp 60位点是明显的;亚型XIIa在全世界的反刍动物中发现，亚型家族XIIb-XIId在美国的啮齿动物中发现，XIIe和XIIf在斯洛伐克共和国的啮齿动物中发现。美国的人类感染了亚型XIIb-XIId的分离株，而其他地区的人主要感染了亚型XIIa的分离株。此外，在美国饮用水源水中检测到XIIb和XIId亚型家族。接触C。感染泛素的绵羊和受感染野生动物污染的饮用水可能是人类感染的来源。
Cryptosporidium ubiquitum is an emerging zoonotic pathogen. In the past, it was not possible to identify an association between cases of human and animal infection. We conducted a genomic survey of the species, developed a subtyping tool targeting the 60-kDa glycoprotein (gp60) gene, and identified 6 subtype families (XIIa–XIIf) of C. ubiquitum. Host adaptation was apparent at the gp60 locus; subtype XIIa was found in ruminants worldwide, subtype families XIIb–XIId were found in rodents in the United States, and XIIe and XIIf were found in rodents in the Slovak Republic. Humans in the United States were infected with isolates of subtypes XIIb–XIId, whereas those in other areas were infected primarily with subtype XIIa isolates. In addition, subtype families XIIb and XIId were detected in drinking source water in the United States. Contact with C. ubiquitum–infected sheep and drinking water contaminated by infected wildlife could be sources of human infections.
登录
查看更多内容
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.
影响因子：
2.1
作者：
Feng, Yaoyu;Lal, Ashima A.;Xiao, Lihua
通讯作者：
Xiao, Lihua
影响因子：
2.6
作者：
da Silva, AJ;Cacciò, S;Eberhard, ML
通讯作者：
Eberhard, ML
影响因子：
2
作者：
Elwin, Kristin;Chalmers, Rachel M.
通讯作者：
Chalmers, Rachel M.
影响因子：
2.3
作者：
Van Dyke, Michele I.;Ong, Corinne S. L.;Huck, Peter M.
通讯作者：
Huck, Peter M.