Pathogenic associations between oral and gastrointestinal diseases.
Pathogenic associations between oral and gastrointestinal diseases.
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DOI：
10.1016/j.molmed.2022.05.006
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发表时间：
2022-12
影响因子：
13.6
通讯作者：
Kamada, Nobuhiko
中科院分区：
文献类型：
--
作者：
Newman, Kira L.;Kamada, Nobuhiko
牙周炎和炎症性肠病（IBD）都是以异常的宿主免疫应答和失调的微生物群为特征的复杂慢性病症。新的数据显示牙周炎和IBD之间的关联，包括口腔和肠道炎症之间的直接和间接机制联系。直接途径包括促炎微生物从口腔转移到肠道和免疫启动。间接途径涉及全身免疫激活，可能对肠道产生非特异性影响。关于牙周病治疗对IBD病程的影响的数据有限，反之亦然，但早期的报告表明，牙周炎的治疗降低了全身免疫激活，IBD的治疗与牙周炎愈合有关，强调了认识和治疗这两种疾病的重要性。
Both periodontitis and inflammatory bowel disease (IBD) are complex chronic conditions characterized by aberrant host immune response and dysregulated microbiota. Emerging data show an association between periodontitis and IBD, including direct and indirect mechanistic links between oral and intestinal inflammation. Direct pathways include translocation of pro-inflammatory microbes from the oral cavity to the gut and immune priming. Indirect pathways involve systemic immune activation with possible non-specific effects on the gut. There are limited data on the effects of periodontal disease treatment on IBD course and vice-versa, but early reports suggest that treatment of periodontitis decreases systemic immune activation and that treatment of IBD is associated with periodontitis healing, underscoring the importance of recognizing and treating both conditions.
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DOI：
10.1126/science.aan4526
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Suda W;Luo C;Kawaguchi T;Motoo I;Narushima S;Kiguchi Y;Yasuma K;Watanabe E;Tanoue T;Thaiss CA;Sato M;Toyooka K;Said HS;Yamagami H;Rice SA;Gevers D;Johnson RC;Segre JA;Chen K;Kolls JK;Elinav E;Morita H;Xavier RJ;Hattori M;Honda K
通讯作者：
Honda K
影响因子：
4.9
作者：
Bitton, Alain;Vutcovici, Maria;Brassard, Paul
通讯作者：
Brassard, Paul
影响因子：
6.7
作者：
Hugoson, Anders;Sjodin, Bengt;Norderyd, Ola
通讯作者：
Norderyd, Ola
影响因子：
35.7
作者：
Alatab, Sudabeh;Sepanlou, Sadaf G.;Naghavi, Mohsen
通讯作者：
Naghavi, Mohsen
影响因子：
6.7
作者：
Groessner-Schreiber, Birte;Fetter, Thomas;Jepsen, Soren
通讯作者：
Jepsen, Soren