On the need and speed of regulating triclosan and triclocarban in the United States.
On the need and speed of regulating triclosan and triclocarban in the United States.
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DOI：
10.1021/es500495p
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发表时间：
2014-04-01
影响因子：
11.4
通讯作者：
Halden, Rolf U.
中科院分区：
文献类型：
--
作者：
Halden, Rolf U.
多氯芳香族抗菌剂三氯生和三氯卡班广泛用于无差别、快速和通过非特异性作用杀死微生物。虽然它们在医疗保健环境中的实用性是无可争议的，但抗菌个人护理产品对用户的益处很少。然而，后者的大量使用已经对环境、野生动物和人类造成了广泛的污染。这篇专题文章介绍了美国关于持久性多氯杀生物剂的科学证据和监管行动的时间轴，显示了明智和可持续使用合成抗菌剂的潜在途径，包括设计更环保和更安全的下一代替代品。多氯芳香族抗菌剂三氯生和三氯卡班广泛用于无差别、快速和通过非特异性作用杀死微生物。虽然它们在医疗保健环境中的实用性是无可争议的，但抗菌个人护理产品对用户的益处很少。然而，后者的大量使用已经对环境、野生动物和人类造成了广泛的污染。这篇专题文章介绍了美国关于持久性多氯杀生物剂的科学证据和监管行动的时间轴，显示了明智和可持续使用合成抗菌剂的潜在途径，包括设计更环保和更安全的下一代替代品。
The polychlorinated aromatic antimicrobials triclosan and triclocarban are in widespread use for killing microorganisms indiscriminately, rapidly, and by nonspecific action. While their utility in healthcare settings is undisputed, benefits to users of antimicrobial personal care products are few to none. Yet, these latter, high-volume uses have caused widespread contamination of the environment, wildlife, and human populations. This feature article presents a timeline of scientific evidence and regulatory actions in the U.S. concerning persistent polychlorinated biocides, showing a potential path forward to judicious and sustainable uses of synthetic antimicrobials, including the design of greener and safer next-generation alternatives. The polychlorinated aromatic antimicrobials triclosan and triclocarban are in widespread use for killing microorganisms indiscriminately, rapidly, and by nonspecific action. While their utility in healthcare settings is undisputed, benefits to users of antimicrobial personal care products are few to none. Yet, these latter, high-volume uses have caused widespread contamination of the environment, wildlife, and human populations. This feature article presents a timeline of scientific evidence and regulatory actions in the U.S. concerning persistent polychlorinated biocides, showing a potential path forward to judicious and sustainable uses of synthetic antimicrobials, including the design of greener and safer next-generation alternatives.
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影响因子：
10.4
作者：
Ahn KC;Zhao B;Chen J;Cherednichenko G;Sanmarti E;Denison MS;Lasley B;Pessah IN;Kültz D;Chang DP;Gee SJ;Hammock BD
通讯作者：
Hammock BD
影响因子：
12.7
作者：
Aiello, Allison E.;Coulborn, Rebecca M.;Larson, Elaine L.
通讯作者：
Larson, Elaine L.
影响因子：
11.4
作者：
Anastas, PT;Zimmerman, JB
通讯作者：
Zimmerman, JB
影响因子：
4.9
作者：
Aiello, AE;Marshall, B;Larson, E
通讯作者：
Larson, E
影响因子：
9.8
作者：
Al-Rajab, Abdul Jabbar;Sabourin, Lyne;Topp, Edward
通讯作者：
Topp, Edward