Sex Differences in Cortisol Level and Neurobehavioral Disinhibition in Children of Substance Abusers
Sex Differences in Cortisol Level and Neurobehavioral Disinhibition in Children of Substance Abusers
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药物滥用者儿童皮质醇水平和神经行为去抑制的性别差异
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
M. Vanyukov
中科院分区：
文献类型：
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作者：
K. Pajer;W. Gardner;G. Kirillova;M. Vanyukov
SUMMARY This investigation determined the extent to which cortisol level, an index of HPA axis activity, covaries with neurobehavioral disinhibition. The sample consisted of 369 boys and 91 girls who were assigned to either a high average risk (HAR) group or a low average risk (LAR) group based on the presence or absence of paternal substance use disorder (SUD). Neurobehavioral disinhibition was assessed using a combination of questionnaires and neuropsychological tests. Saliva was collected for cortisol determination during a mild stressor and again 35 minutes after the task. The results indicated that disinhibition was higher and cortisol level lower in boys compared to girls. Cortisol level was negatively correlated with severity of neurobehavioral disinhibition in girls, accounting for 24% of the variance. A similar trend was observed in the boys; however, the correlation did not attain statistical significance. Based on these findings, it is tentatively concluded that boys and girls differ with respect to biochemical indicators of stress reactivity underlying neurobehavioral disinhibition, a putative phenotype associated with the liability for SUD.
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DOI：
10.1210/jcem.81.7.8675562
发表时间：
1996-07
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
E. Cauter;R. Leproult;D. Kupfer
通讯作者：
E. Cauter;R. Leproult;D. Kupfer
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DOI：
10.1016/s0899-3289(10)80001-x
发表时间：
1990
期刊：
Journal of substance abuse
影响因子：
--
作者：
Labouvie,EW;Pandina,RJ;White,HR;Johnson,V
通讯作者：
Johnson,V
父母酗酒与青少年物质使用的关系：一项纵向随访研究。
影响因子：
4.6
作者：
Chassin,L;Curran,PJ;Hussong,AM;Colder,CR
通讯作者：
Colder,CR
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影响因子：
4.6
作者：
Chassin,L;Pitts,SC;DeLucia,C;Todd,M
通讯作者：
Todd,M
青少年酒精使用和问题使用的前瞻性差异预测：检查效果机制。
影响因子：
4.6
作者：
Stice,E;BarreraJr,M;Chassin,L
通讯作者：
Chassin,L