The Expression Profile and Prognostic Values of EPHA Family Members in Breast Cancer.
The Expression Profile and Prognostic Values of EPHA Family Members in Breast Cancer.
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EPHA家族成员在乳腺癌中的表达谱及预后价值
DOI：
10.3389/fonc.2021.619949
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Zhang X
EphAs是属于膜结合受体酪氨酸激酶组的一类肝配蛋白受体。越来越多的实验证据表明，EphA家族参与肿瘤进展，即参与细胞增殖、侵袭和转移。EphAs是一种有前途的抗癌治疗靶点。然而，它们在乳腺癌（BC）中的作用仍然没有得到很好的理解。我们使用一系列生物信息学方法来分析EphA家族成员的表达，并研究其在BC中的预后价值。与正常组织相比，在BC组织中发现EphA2、EphA3、EphA4、EphA5和EphA7的较低表达水平和EphA10的较高表达水平。EphA家族基因的表达水平与分子亚型相关，但与肿瘤分期无关。大多数EphAs的高表达水平表明BC的预后较好。这项研究表明，EphA2，EphA3，EphA4和EphA5可以作为肿瘤抑制因子以及BC预后的生物标志物。
EphAs are a class of ephrin receptors that belong to the membrane-bound receptor tyrosine kinases group. Accumulating experimental evidence has shown that the EphA family is involved in tumor progression, namely in cell proliferation, invasiveness, and metastasis. EphAs are a promising target for anticancer therapy. However, their role in breast cancer (BC) is still not well understood. We used a series of bioinformatic approaches to analyze the expression of the EphA family members and investigate their prognostic value in BC. Lower expression levels of EphA2, EphA3, EphA4, EphA5, and EphA7 and higher expression levels of EphA10 were found in BC tissues compared to those in normal tissues. The expression levels of the EphA family genes were correlated with molecular subtyping but not with tumor stage. High expression levels of most EphAs indicated a better prognosis in BC. This study suggested that EphA2, EphA3, EphA4, and EphA5 can act as tumor-inhibiting factors as well as biomarkers for the prognosis of BC.
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