Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies.
Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies.
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DOI：
10.1002/ana.23820
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发表时间：
2013-02
影响因子：
11.2
通讯作者：
Ascherio, Alberto
中科院分区：
文献类型：
--
作者：
Fitzgerald, Kathryn C.;O'Reilly, Eilis J.;Fondell, Elinor;Falcone, Guido J.;McCullough, Marjorie L.;Park, Yikyung;Kolonel, Laurence N.;Ascherio, Alberto
先前的研究表明，氧化应激在肌萎缩侧索硬化症（ALS）的发病机制中可能发挥作用。研究膳食抗氧化剂如类胡萝卜素和维生素C的前瞻性数据有限。在5个前瞻性队列中研究了与类胡萝卜素和维生素C摄入相关的ALS风险：美国国立卫生研究院- AARP饮食和健康研究，癌症预防研究II营养队列，多种族队列，卫生专业人员随访研究和护士健康研究。使用国家死亡指数记录ALS死亡，并从HPFS和NHS中纳入确认的非致命性ALS病例。在1，100，910名参与者（562，942名男性; 537，968名女性）中，共发生了1153例ALS死亡。参与者被归类为队列特定的五分之一的饮食变量的摄入量。我们应用考克斯比例风险回归计算队列特异性风险比（RR），并使用随机效应方法汇总结果。主要类胡萝卜素总摄入量增加与ALS风险降低相关（最高至最低五分位数的合并多变量调整RR：0.75; 95%CI：0.61至0.91; P趋势= 0.004）。个别而言，较高的β-胡萝卜素和叶黄素饮食摄入量与ALS风险呈负相关。比较β-胡萝卜素和叶黄素最高与最低五分位数的汇总多变量RR分别为0.85（95% CI：0.64-1.13; P趋势=0.03）和0.79（95% CI：0.64 - 0.96; P趋势=0.01）。番茄红素、β-隐黄素和维生素C与ALS风险降低无关。食用富含类胡萝卜素的食物可能有助于预防或延迟ALS的发作。
Prior research has suggested the possible role of oxidative stress in the pathogenesis of amyotrophic lateral sclerosis (ALS). Prospective data examining dietary antioxidants such carotenoids and vitamin C are limited. Risk of ALS associated with carotenoid and vitamin C intake was investigated in 5 prospective cohorts: the National Institutes of Health – AARP Diet and Health Study, the Cancer Prevention Study II Nutrition Cohort, the Multiethnic Cohort, the Health Professionals Follow-up Study, and the Nurses Health Study. ALS deaths were documented using the National Death Index and confirmed nonfatal ALS cases were included from HPFS and NHS. A total of 1153 ALS deaths occurred among 1,100,910 participants (562,942 men; 537,968 women). Participants were categorized into cohort-specific quintiles of intake for dietary variables. We applied Cox proportional hazards regression to calculate cohort-specific risk ratios (RR), and pooled results using random-effects methods. A greater total major carotenoids intake was associated with a reduced risk of ALS (pooled, multivariable-adjusted RR for the highest to the lowest quintile: 0.75; 95% CI: 0.61 to 0.91; P trend = 0.004). Individually, higher dietary intakes of β-carotene and lutein were inversely associated with ALS risk. The pooled multivariable RRs comparing the highest to the lowest quintile for β- carotene and lutein were 0.85 (95% CI: 0.64–1.13; P trend=0.03) and 0.79 (95% CI: 0.64 to 0.96; P trend=0.01), respectively. Lycopene, β-cryptoxanthin, and vitamin C were not associated with reduced risk of ALS. Consumption of foods high in carotenoids may help prevent or delay onset of ALS.
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影响因子：
11.2
作者：
Ascherio, A;Weisskopf, MG;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
5.3
作者：
Kruman, II;Pedersen, WA;Mattson, MP
通讯作者：
Mattson, MP
影响因子：
5.7
作者：
Longnecker, MP;Kamel, F;Sandler, DP
通讯作者：
Sandler, DP
影响因子：
168.9
作者：
RIMM, EB;GIOVANNUCCI, EL;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N