Development and initial validation of the chronic hepatitis B quality of life instrument (CHBQOL) among Chinese patients
Development and initial validation of the chronic hepatitis B quality of life instrument (CHBQOL) among Chinese patients
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中国患者慢性乙型肝炎生活质量工具（CHBQOL）的开发和初步验证
DOI：
10.1007/s11136-019-02240-7
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发表时间：
2019-06
影响因子：
3.5
通讯作者：
王红妹
中科院分区：
文献类型：
--
作者：
朱琳;孔静霞;郑颖婧;宋孟娜;程潇;张利;Donald L. Patrick;王红妹
目的本研究开发并测试了专门用于测量慢性乙型肝炎患者 HRQOL (CHBQOL) 的中国量表的初步测量特性。方法我们对 CHB 患者进行了 94 名个人访谈以征求项目，并进行了 5 名肝炎专家访谈以及三轮认知访谈，以确定与内容相关和理解的问题。然后进行横断面验证研究来评估测量特性 (n= 578)。使用因子分析来确定量表的潜在结构。可靠性通过 Cronbach α 系数和组内相关系数 (ICC) 进行评估。还检查了测量模型的充分性、收敛性、判别性和已知群体的有效性。结果起草了30个项目的量表。项目减少后，剩余23个项目被分配到CHBQOL躯体症状、情绪症状、信仰和社会耻辱领域，其拟合优度可接受（χ2/df= 3.13，GFI = 0.90，AGFI = 0.88，RMSEA = 0.06， SRMR = 0.05）。所有 CHBQOL 域均具有令人满意的信度，Cronbach’s α 系数范围为 0.73 至 0.91，除 Belief 域（ICC = 0.54）外，ICC 均高于 0.70。由于显着的项目域相关性 (0.64–0.90) 的支持，收敛效度和判别效度是可以接受的。一般来说，CHBQOL 和 SF-36 维度之间的相关性符合假设。人口统计学和临床变量亚组的平均得分存在显着差异，支持已知组的有效性。结论 CHBQOL 工具被证明是评估中国 CHB 患者 HRQOL 的合适工具。
PurposeThis study developed and tested preliminary measurement properties of a Chinese scale specifically designed to measure HRQOL in patients with chronic hepatitis B (CHBQOL).MethodsWe conducted 94 individual interviews with CHB patients to solicit items and five hepatitis expert interviews along with three rounds of cognitive interviews to identify problems with relevance and understanding of content. A cross-sectional validation study was then conducted to evaluate measurement properties (n= 578). Factor analysis was used to determine the latent structure of the scale. Reliability was evaluated through Cronbach’s alpha coefficients and intra-class correlation coefficients (ICCs). Measurement model adequacy, convergent, discriminant, and known-groups validity were also examined.ResultsA scale of 30 items was drafted. After item reduction, the remaining 23 items were assigned to the CHBQOL Somatic symptoms, Emotional symptoms, Belief and Social stigma domains, which had acceptable goodness of fit (χ2/df= 3.13, GFI = 0.90, AGFI = 0.88, RMSEA = 0.06, SRMR = 0.05). All the CHBQOL domains had satisfactory reliability with Cronbach’s α coefficients ranging from 0.73 to 0.91 and ICCs were higher than 0.70 except for Belief domain (ICC = 0.54). Convergent and discriminant validity were acceptable as supported by significant item-domain correlations (0.64–0.90). In general, the correlations between CHBQOL and the SF-36 dimensions met hypotheses. Significant differences were found by mean scores in the subgroups of demographic and clinical variables, supporting the known-groups validity.ConclusionsThe CHBQOL instrument proved to be an appropriate tool for assessing HRQOL among Chinese CHB patients.
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影响因子：
3.7
作者：
Liu Y;Zhang S;Zhao Y;Du J;Jin G;Shao S;Lu X
通讯作者：
Lu X
DOI：
10.1016/0140-6736(93)91495-8
发表时间：
1993-06
期刊：
The Lancet
影响因子：
--
作者：
Jan Hawthorn
通讯作者：
Jan Hawthorn
DOI：
--
发表时间：
2003-03
期刊：
--
影响因子：
--
作者：
Richard G. Netemeyer;Subhash Sharma;W. O. Bearden
通讯作者：
Richard G. Netemeyer;Subhash Sharma;W. O. Bearden
DOI：
10.1097/meg.0b013e328347322b
发表时间：
2011-08-01
影响因子：
2.1
作者：
Luo, Zhuanbo;Xie, Yirui;Ruan, Bing
通讯作者：
Ruan, Bing
DOI：
10.15353/cgjsc-rcessc.v1i1.25
发表时间：
2012-07
期刊：
--
影响因子：
--
作者：
Nassim Tabri;C. M. Elliott
通讯作者：
Nassim Tabri;C. M. Elliott