Development and Application of the Chinese (Mainland) Version of Chronic Liver Disease Questionnaire to Assess the Health-Related Quality of Life (HRQoL) in Patients with Chronic Hepatitis B.
Development and Application of the Chinese (Mainland) Version of Chronic Liver Disease Questionnaire to Assess the Health-Related Quality of Life (HRQoL) in Patients with Chronic Hepatitis B.
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DOI：
10.1371/journal.pone.0162763
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Lu X
中科院分区：
文献类型：
--
作者：
Liu Y;Zhang S;Zhao Y;Du J;Jin G;Shao S;Lu X
开发中国（大陆）版慢性肝病问卷（CLDQ），并用其评估中国慢性乙型肝炎（CHB）患者的健康相关生活质量（HRQoL），并确定HRQoL的决定因素。中国（大陆）CLDQ是通过专家咨询、患者焦点小组访谈和试点研究制定的。采用最终版本的问卷对北京两家最大的传染病医院入组的慢性乙型肝炎门诊患者的HRQoL进行评估。 Cronbach’s alpha 用于衡量内部一致性信度。通过因子分析来测量结构效度。使用 T 检验、单因素方差分析 (ANOVA) 和多变量线性回归来分析数据。整体 CLDQ 的 Cronbach α 值为 0.935，六个分量表的范围为 0.628 至 o.881。通过因素分析确定了六个因素，其中包括一个新的因素睡眠（SL）。最终版问卷共纳入519例慢性乙型肝炎患者，其中405例为单纯慢性乙型肝炎，53例为代偿性肝硬化，61例为失代偿性肝硬化。 CHB组在CLDQ总分中得分最高（p<0.05）。补偿组的担忧得分 (WO) 显着低于 CHB 组 (p<0.05)。失代偿期肝硬化患者在所有 CLDQ 领域和总分上的得分均低于 CHB 组 (p<0.05)。疾病阶段、性别、定期去专科医院就诊以及去年的工作状况是HRQoL的决定因素。中国（大陆）CLDQ 的心理测量特性是可以接受的。 CHB 患者的 HRQoL 随着疾病进展而恶化。慢性乙型肝炎晚期、女性、病后长期缺勤以及没有工作或退休是 HRQoL 较差的决定因素。定期去专科医院就诊是 HRQoL 的积极决定因素。
To develop the Chinese (Mainland) version of Chronic Liver Disease Questionnaire (CLDQ) and use it to assess the health-related quality of life (HRQoL) of chronic hepatitis B (CHB) patients in China and identify the determinants of HRQoL. The Chinese (Mainland) CLDQ was developed by expert consultation, focus group interviews with patients, and pilot study. The final version of questionnaire was adopted to assess the HRQoL of chronic hepatitis B outpatients enrolled from two largest infectious hospitals in Beijing. Cronbach’ s alpha was used to measure the internal consistency reliability. The construct validity was measured by factor analysis. T-test, one-way analysis of variance (ANOVA), and multi-variable linear regression were used to analyze the data. Cronbach’s alpha of the overall CLDQ is 0.935, ranging from 0.628 to o.881 among six subscales. Six factors were identified via factor analysis, including a new factor sleeping(SL). A total of 519 patients with CHB were included in the investigation with the final version of questionnaire, 405 of them were only with CHB, 53 with compensated cirrhosis, and 61 with decompensated cirrhosis. The CHB group scored the highest in the overall score of CLDQ (p<0.05). The score of worry (WO) domain was significantly lower in the compensated group than the CHB group (p<0.05). Decompensated cirrhosis patients scored lower than the CHB group in all CLDQ domains and the overall score (p<0.05). Stages of illness, gender, regular visits to specialized hospitals, and work status in last year were determinants of HRQoL. The psychometric properties of the Chinese(Mainland) CLDQ is acceptable. The HRQoL of CHB patients deteriorated with disease progression. Advanced stages of CHB, female, long time absence from work after illness, and no job or retirement were determinants of poor HRQoL. Regular visits to specialized hospitals was a positive determinant of HRQoL.
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