The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.
The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.
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雌激素及其受体在感染过程中对免疫和炎症的影响。
DOI：
10.3390/cancers14040909
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发表时间：
2022-02-12
期刊：
影响因子：
5.2
通讯作者：
Heaton NS
中科院分区：
文献类型：
--
作者：
Harding AT;Heaton NS
微生物感染严重影响人类健康。这类感染后果的最大决定因素之一是宿主免疫反应。反应太弱可能会导致病原体的传播增强，而过度刺激的反应可能会导致免疫诱导的组织损伤。因此，为了有效地治疗感染者，了解控制炎症反应的调节因素至关重要。最近，雌激素作为性激素的一种，能够显著改变宿主细胞对微生物的反应，这一点已被广泛接受。在这篇综述中，我们讨论了雌激素如何改变宿主的免疫反应，以及这些改变如何改变个体感染的结果。性激素，如雌激素和睾酮，是类固醇化合物，对脊椎动物生殖系统的协调和发育具有很好的特性。然而，自从它们被发现以来，很明显，这些“性激素”也调节/影响着广泛的生物功能。在这篇综述中，我们将总结一些关于雌激素如何与炎症和免疫相互作用并调节炎症和免疫的最新研究结果。具体地说，我们将重点描述雌激素改变免疫途径激活的机制，这些变化在感染和长期免疫发展过程中的影响，以及不同类型的雌激素及其各自的浓度如何调节这些结果。
Human health is significantly affected by microbial infections. One of the largest determinants of the outcomes of such infections is the host immune response. Too weak of a response can lead to enhanced spread by the pathogen, while an overstimulated response can lead to immune-induced tissue damage. Thus, to effectively treat infected individuals, it is critical to understand the regulators that control inflammatory responses. Recently, it has become widely accepted that estrogens, a class of sex hormones, are capable of dramatically altering the responses of host cells to microbes. In this review, we discuss how estrogens change the host immune response, as well as how these changes can alter the outcome of the infection for the individual. Sex hormones, such as estrogen and testosterone, are steroid compounds with well-characterized effects on the coordination and development of vertebrate reproductive systems. Since their discovery, however, it has become clear that these “sex hormones” also regulate/influence a broad range of biological functions. In this review, we will summarize some current findings on how estrogens interact with and regulate inflammation and immunity. Specifically, we will focus on describing the mechanisms by which estrogens alter immune pathway activation, the impact of these changes during infection and the development of long-term immunity, and how different types of estrogens and their respective concentrations mediate these outcomes.
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DOI：
10.4049/jimmunol.1601896
发表时间：
2017-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Channappanavar R;Fett C;Mack M;Ten Eyck PP;Meyerholz DK;Perlman S
通讯作者：
Perlman S
影响因子：
2.8
作者：
Ben Salah-Abbes, Jalila;Belgacem, Hela;Abbes, Samir
通讯作者：
Abbes, Samir
影响因子：
--
作者：
Cheng, G;Yeater, KM;Hoyer, LL
通讯作者：
Hoyer, LL
影响因子：
4.2
作者：
Bulgaru CV;Marin DE;Pistol GC;Taranu I
通讯作者：
Taranu I
影响因子：
6.7
作者：
Al-Raddadi, Rajaa M.;Shabouni, Omaima, I;Madani, Tariq A.
通讯作者：
Madani, Tariq A.