Zearalenone and the Immune Response.
Zearalenone and the Immune Response.
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DOI：
10.3390/toxins13040248
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发表时间：
2021-03-31
期刊：
影响因子：
4.2
通讯作者：
Taranu I
中科院分区：
文献类型：
--
作者：
Bulgaru CV;Marin DE;Pistol GC;Taranu I
玉米赤霉烯酮（ZEA）是一种雌激素类镰刀菌毒素，被归类为植物雌激素或真菌雌激素。ZEA及其代谢产物能够与雌激素受体（17β-雌二醇特异性受体）结合，导致生殖障碍，包括生育力低下、胎儿发育异常、窝仔数减少和生殖激素水平改变，尤其是在母猪中。ZEA对免疫应答也有显著影响，具有免疫刺激或免疫抑制结果。本文综述了ZEA及其衍生物对各种免疫应答水平的影响，如以炎症应答为主要成分的先天免疫以及以体液和细胞免疫应答为两种成分的获得性免疫。ZEA在触发其影响所涉及的机制进行了处理。该综述引用了150多篇出版物，并讨论了从体外和体内实验中获得的结果，这些实验探索了ZEA对不同类型的免疫细胞（与先天免疫相关的吞噬细胞和与获得性免疫相关的淋巴细胞）以及免疫器官产生的免疫毒性。综述表明，尽管越来越多的研究分析ZEA调节免疫反应的机制，但现有的数据是不充分的，需要进一步的工作。
Zearalenone (ZEA) is an estrogenic fusariotoxin, being classified as a phytoestrogen, or as a mycoestrogen. ZEA and its metabolites are able to bind to estrogen receptors, 17β-estradiol specific receptors, leading to reproductive disorders which include low fertility, abnormal fetal development, reduced litter size and modification at the level of reproductive hormones especially in female pigs. ZEA has also significant effects on immune response with immunostimulatory or immunosuppressive results. This review presents the effects of ZEA and its derivatives on all levels of the immune response such as innate immunity with its principal component inflammatory response as well as the acquired immunity with two components, humoral and cellular immune response. The mechanisms involved by ZEA in triggering its effects are addressed. The review cited more than 150 publications and discuss the results obtained from in vitro and in vivo experiments exploring the immunotoxicity produced by ZEA on different type of immune cells (phagocytes related to innate immunity and lymphocytes related to acquired immunity) as well as on immune organs. The review indicates that despite the increasing number of studies analyzing the mechanisms used by ZEA to modulate the immune response the available data are unsubstantial and needs further works.
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影响因子：
4.3
作者：
Cavret, S;Lecoeur, S
通讯作者：
Lecoeur, S
影响因子：
2.8
作者：
Ben Salah-Abbes, Jalila;Belgacem, Hela;Abbes, Samir
通讯作者：
Abbes, Samir
影响因子：
2
作者：
Bakker, Matthew G.;Brown, Daren W.;Ward, Todd J.
通讯作者：
Ward, Todd J.
影响因子：
4.2
作者：
Benthem de Grave X;Saltzmann J;Laurain J;Rodriguez MA;Molist F;Dänicke S;Santos RR
通讯作者：
Santos RR
影响因子：
2.8
作者：
Busk, Oyvind L.;Ndossi, Doreen;Sorlie, Morten
通讯作者：
Sorlie, Morten