HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.
HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.
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突发感染者之间的艾滋病毒-1传播联系，为公共卫生监测提供信息。
DOI：
10.1016/j.eclinm.2021.100968
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发表时间：
2021-07
影响因子：
15.1
通讯作者：
Eron JJ
中科院分区：
文献类型：
--
作者：
Dennis AM;Frost SDW;Enders K;Cressman AE;Volz E;Adams N;Miller WC;Cohen MS;Mobley V;Samoff E;Eron JJ
我们评估了涉及艾滋病毒感染事件 (IHI) 期间被诊断者的艾滋病毒传播网络的特征，以评估基于网络的遏制进一步传播的机会。传播网络是使用北卡罗莱纳州近期（2014-2018）和过去（<2014）HIV诊断人群监测报告的部分pol序列构建的。 IHI 被定义为有记录的急性感染或血清转化。对涉及 ≥ 1 IHI 的 HIV 基因簇（<1.5% 成对遗传距离）的人口统计学和病毒学特征进行了评估。对具有病毒遗传联系且在 IHI 前 90 天以上进行诊断的人进行了进一步的特征分析。我们使用接触者追踪数据评估了 IHI 指数人群中指定合作伙伴的结果。在 2014 年至 2018 年 4,405 例 HIV 诊断序列中，有 323 例 (7%) 为 IHI 指数人；大多数是男性 (88%)、黑人 (65%)、年轻人 (68% <30 岁)，并报告有男男性行为 (MSM) 风险 (79%)。与同期诊断的非指标人群相比，指标人群更有可能成为集群成员（72% vs. 49%）。总共发现了 162 个聚集性病例，涉及 233 例 IHI、577 例近期诊断和 163 例既往诊断。大多数 IHI 病例 (53%) 与 ≥1 名先前诊断的人有病毒联系，但在 IHI 指数诊断前一年没有 HIV 病毒抑制的证据。在接触者追踪中，只有 53% 的 IHI 病例提到了 HIV 阳性接触者，导致每次 IHI 调查中检测到 0.5 名先前确诊的人。与病毒分析相结合，先前诊断出的病毒血症患者的检出率增至 1.3。将公共卫生与分子流行病学相结合，发现一半以上的 IHI 与先前诊断出的未抑制的 HIV 感染者存在病毒联系，而传统的接触者追踪在很大程度上无法识别这种联系。加强合作伙伴服务以支持艾滋病毒护理的参与和保留，以及通过快速系统发育分析支持改进病例发现，是大幅减少艾滋病毒继续传播的工具。
We evaluated features of HIV transmission networks involving persons diagnosed during incident HIV infection (IHI) to assess network-based opportunities to curtail onward transmission. Transmission networks were constructed using partial pol sequences reported to North Carolina surveillance among persons with recent (2014–2018) and past (<2014) HIV diagnoses. IHI were defined as documented acute infections or seroconversion. Demographic and virologic features of HIV genetic clusters (<1.5% pairwise genetic distance) involving ≥ 1 IHI were assessed. Persons with viral genetic links and who had diagnoses >90 days prior to an IHI were further characterized. We assessed named partner outcomes among IHI index persons using contact tracing data. Of 4,405 HIV diagnoses 2014–2018 with sequences, there were 323 (7%) IHI index persons; most were male (88%), Black (65%), young (68% <30 years), and reported sex with men (MSM) risk (79%). Index persons were more likely to be cluster members compared to non-index persons diagnosed during the same period (72% vs. 49%). In total, 162 clusters were identified involving 233 IHI, 577 recent diagnoses, and 163 past diagnoses. Most IHI cases (53%) had viral linkages to ≥1 previously diagnosed person without evidence of HIV viral suppression in the year prior to the diagnosis of the IHI index. In contact tracing, only 53% IHI cases named an HIV-positive contact, resulting in 0.5 previously diagnosed persons detected per IHI investigated. When combined with viral analyses, the detection rate of viremic previously diagnosed persons increased to 1.3. Integrating public health with molecular epidemiology, revealed that more than half of IHI have viral links to persons with previously diagnosed unsuppressed HIV infection which was largely unrecognized by traditional contact tracing. Enhanced partner services to support engagement and retention in HIV care and improved case finding supported by rapid phylogenetic analysis are tools to substantially reduce onward HIV transmission.
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DOI：
10.1097/qad.0000000000001555
发表时间：
2017-08-24
期刊：
AIDS (London, England)
影响因子：
--
作者：
Dalal S;Johnson C;Fonner V;Kennedy CE;Siegfried N;Figueroa C;Baggaley R
通讯作者：
Baggaley R
DOI：
10.1097/qai.0b013e3181ac12bf
发表时间：
2009-12-01
影响因子：
3.6
作者：
Moore, Zack S.;McCoy, Sandi;Leone, Peter
通讯作者：
Leone, Peter
影响因子：
5.6
作者：
Bradley, Heather;Hogan, Vicki;Hoots, Brooke E.
通讯作者：
Hoots, Brooke E.
影响因子：
33.9
作者：
Golden, Matthew R.;Lechtenberg, Richard;Buskin, Susan E.
通讯作者：
Buskin, Susan E.
影响因子：
33.9
作者：
Dasgupta, Sharoda;Oster, Alexandra M.;Hall, H. Irene
通讯作者：
Hall, H. Irene