Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers.
Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers.
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DOI：
10.1111/acer.14381
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Boissoneault J
中科院分区：
文献类型：
--
作者：
Sevel L;Stennett B;Schneider V 2nd;Bush N;Nixon SJ;Robinson M;Boissoneault J
急性酒精中毒对精神、注意力、抑制和记忆相关的认知过程有广泛的神经行为影响。这些影响反映在神经代谢、功能激活和功能网络连贯性的破坏中。区域内神经动力学（如区域信号变异性（RSV）和脑熵（BEN））的测量可能会捕获健康和临床人群神经功能能力的独特方面;然而，酒精对这些指标的影响尚不清楚。本研究旨在阐明急性酒精中毒对RSV的影响，并通过随后的BEN分析阐明这些影响。26名年龄在25至45岁之间的健康成年人（65.4%为女性）参加了两次平衡训练。在一项研究中，参与者饮用了含有酒精的饮料，足以产生0.08 g/dL的呼气酒精浓度。在另一组中，他们喝了安慰剂饮料。在饮用饮料约35分钟后，参与者完成了9分钟的静息状态fMRI扫描。使用全脑体素标准差来评估RSV，并在疗程之间进行比较。在显示RSV改变的簇内，计算样品熵以评估BEN。与安慰剂组相比，酒精摄入导致双侧中额叶、右下额叶、右上级额叶、双侧后扣带回、双侧中颞叶、右侧缘上回和双侧顶下小叶的RSV普遍降低。在这些集群中，发现双侧额中回和右侧额上级回BEN显著降低。在皮质下或小脑区域未观察到影响。研究结果表明，酒精的摄入量与注意力过程相关的结构之间的RSV产生弥漫性减少。在这些结构中，信号的复杂性也降低了一个子集的额叶区域。急性饮酒的神经行为影响可能部分是由于参与高阶认知和注意力过程的区域间区域内神经动力学的破坏。
Acute alcohol intoxication has wide-ranging neurobehavioral effects on psychomotor, attentional, inhibitory, and memory-related cognitive processes. These effects are mirrored in disruption of neural metabolism, functional activation, and functional network coherence. Metrics of intraregional neural dynamics such as regional signal variability (RSV) and brain entropy (BEN) may capture unique aspects of neural functional capacity in healthy and clinical populations; however, alcohol’s influence on these metrics is unclear. The present study aimed to elucidate the influence of acute alcohol intoxication on RSV and to clarify these effects with subsequent BEN analyses. 26 healthy adults between 25 and 45 years of age (65.4% women) participated in two counterbalanced sessions. In one, participants consumed a beverage containing alcohol sufficient to produce a breath alcohol concentration of 0.08 g/dL. In the other, they consumed a placebo beverage. Approximately 35 minutes after beverage consumption, participants completed a 9-minute resting state fMRI scan. Whole brain, voxel-wise standard deviation was used to assess RSV, which was compared between sessions. Within clusters displaying alterations in RSV, sample entropy was calculated to assess BEN. Compared to the placebo, alcohol intake resulted in widespread reductions in RSV in the bilateral middle frontal, right inferior frontal, right superior frontal, bilateral posterior cingulate, bilateral middle temporal, right supramarginal gyri, and bilateral inferior parietal lobule. Within these clusters, significant reductions in BEN were found in the bilateral middle frontal and right superior frontal gyri. No effects were noted in subcortical or cerebellar areas. Findings indicate that alcohol intake produces diffuse reductions in RSV among structures associated with attentional processes. Within these structures, signal complexity was also reduced in a subset of frontal regions. Neurobehavioral effects of acute alcohol consumption may be partially driven by disruption of intraregional neural dynamics among regions involved in higher order cognitive and attentional processes.
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影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
影响因子：
5.7
作者：
Gauthier, C. J.;Fan, A. P.
通讯作者：
Fan, A. P.
影响因子：
10.6
作者：
Gan G;Guevara A;Marxen M;Neumann M;Jünger E;Kobiella A;Mennigen E;Pilhatsch M;Schwarz D;Zimmermann US;Smolka MN
通讯作者：
Smolka MN
影响因子：
4.2
作者：
Boissoneault, Jeff;Stennett, Bethany;Robinson, Michael E.
通讯作者：
Robinson, Michael E.
影响因子：
1.9
作者：
GALLEZ, D;BABLOYANTZ, A
通讯作者：
BABLOYANTZ, A